Search for dissertations about: "BRCA1 and BRCA2"
Showing result 21 - 25 of 36 swedish dissertations containing the words BRCA1 and BRCA2.
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21. Genetic predisposition for cancer : genes and genetic counseling
Abstract : Breast cancer accounts for one third of all female cancer cases worldwide. A hereditary component accounts for 10-15% of all breast and ovarian cancer cases. The overall aim of this thesis is to evaluate and improve genetic diagnostic and genetic counseling in hereditary cancer patients. READ MORE
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22. Biochemical markers and genetic risk factors in canine tumors
Abstract : One out of four dogs will develop cancer before the age of 10 years. Many of them will succumb to the disease. Risk factor analysis, tumor prevention, and ways to prognosticate already existing tumors in the individual patient, are important. READ MORE
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23. Evaluation of genetic cancer predisposition and potential cancer genes
Abstract : Germline pathogenic TP53 variants are associated with a broad spectrum of hereditary cancers characterized from Li-Fraumeni syndrome (LFS) to hereditary breast cancer (HBC) outcomes, known as heritable TP53-related cancer (hTP53rc) syndrome. LFS is a rare inherited cancer syndrome characterized by premenopausal breast cancer, soft tissue sarcoma, brain tumor, osteosarcoma, and adrenocortical carcinoma. READ MORE
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24. Investigation of the genetic basis of familial non-BRCA1/2 breast cancer
Abstract : Breast cancer is the most common female malignancy in the Western world and approximately 510% of all breast cancer cases present with some degree of family history. In the mid-nineties genetic linkage analyses successfully identified two breast cancer predisposing genes, BRCA1 and BRCA2. READ MORE
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25. Search for susceptibility loci and candidate genes for breast cancer
Abstract : Breast cancer is the most frequent cancer among women in the western world. Family history is a wellestablished and important risk factor for breast cancer. Both a population-based twin study and a study based on a large family cancer database have suggested that hereditary factors account for about a quarter of breast cancers. READ MORE