Search for dissertations about: "BRCA2"

Showing result 21 - 25 of 45 swedish dissertations containing the word BRCA2.

  2. 21. Treatment of BRCA1/2-associated breast cancer and identification of mutation carriers among breast cancer patients

    Author : Martin Nilsson; Tumörmikromiljö; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : The general aim of the research presented in this thesis was to contribute to the understanding of how breast cancer patients with germline BRCA1/2 mutations should be treated medically and surgically, and furthermore, to characterize the limitations and strengths of different procedures for BRCA testing. In Paper I, the long-term prognosis was assessed in a cohort of early-onset breast cancer patients (n = 221). READ MORE

  4. 22. A genetic study on familial breast cancer predisposing genes

    Author : Liping Luo; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Breast cancer is the most common malignant disease among women in the western world and 10% of all breast cancer is assumed to constitute hereditary cases. Two major genes, BRCA1 and BRCA2, can only explain a fraction of familial breast cancer. The ATM carriers have high risk of developing breast cancer. READ MORE

  5. 23. Investigation of the genetic basis of familial non-BRCA1/2 breast cancer

    Author : Paula Maguire; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Familial non-BRCA1 2 breast cancer; linkage analysis; CGH; association study;

    Abstract : Breast cancer is the most common female malignancy in the Western world and approximately 510% of all breast cancer cases present with some degree of family history. In the mid-nineties genetic linkage analyses successfully identified two breast cancer predisposing genes, BRCA1 and BRCA2. READ MORE

  6. 24. Genetic studies in familial non-BRCA breast cancer

    Author : Camilla Wendt; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Family history is an important risk factor for breast cancer, the presence of breast cancer in a first degree relative in general nearly doubles the risk and the risk increases with the number of affected relatives. Pathogenic mutations in BRCA1, BRCA2 and other high- and moderate risk-genes account for 25% of the familial risk for breast cancer. READ MORE

  7. 25. Genetic and Epigenetic Characterisation of Breast Tumours

    Author : Karolina Holm; Bröstcancer-genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast cancer; PIK3CA; PTEN; PI3K pathway; CCND1; microarrays; molecular subtypes; DNA methylation; EZH2; H3K27me3; PRC2; histone modification;

    Abstract : Breast tumours harbour a large amount of genetic and epigenetic alterations, which are associated with e.g. tumour aggressiveness, prognosis, and response to therapy. READ MORE