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Showing result 1 - 5 of 9 swedish dissertations matching the above criteria.
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1. The p97 ATPase and the Drosophila Proteasome : Protein Unfolding and Regulation
Abstract : For all living systems, there is a requirement to recycle and regulate proteins. In eukaryotic organisms this is accomplished by the proteasome. The p97 ATPase is another highly conserved and essential complex present throughout the eukaryotic cell. READ MORE
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2. Unravelling Mechanistic Insights of Eukaryotic Transcriptional Control
Abstract : DNA transcription involves the association of multiple proteins with DNA to convert the genetic information into messenger-RNA transcripts, which later will be translated into proteins. Con-trolled regulation of transcription is imperative for preserving the healthy and homeostatic state of cells. READ MORE
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3. Studies of the C/EBP family of transcription factors : cloning, regulation, and expression
Abstract : The CCAAT/Enhancer Binding Protein (C/EBP) family belongs to the basic leucine zipper class of transcription factors with a total of 6 members having been identified in this family so far. This gene family has been mainly implicated in regulation of cell specific gene expression and differentiation. READ MORE
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4. bHLH transcription factors in differentiating neuroblastoma cells
Abstract : Neuroblastoma is a tumor of the sympathetic nervous system, and arises during early childhood. The tumor is highly heterogeneous and evidence, such as expression of genes normally only expressed during embryonic and fetal stages, suggests that the tumor is of embryonic origin and that the tumor arises as a consequence of perturbed differentiation during the development of the sympathetic nervous system. READ MORE
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5. Myc oncoprotein cofactor interactions : function, regulation and targeting
Abstract : The members of the Myc-family of proto-oncoproteins c-Myc, N-Myc and L-Myc are transcription factors exerting their effect via protein-protein interactions. The Myc proteins are basic-helix-loop-helix-leucine-zipper (bHLHzip) transcription factors, which after heterodimerization with their obligatory partner Max, bind to E-boxes in target gene promoters and regulate the expression of 10-15% of all genes by the recruitment of different cofactors. READ MORE