Search for dissertations about: "Bax"

Showing result 1 - 5 of 70 swedish dissertations containing the word Bax.

  1. 1. Modulation of Alzheimer's amyloid β peptide self-assembly : Insights into molecular mechanisms of peptide aggregation associated with Alzheimer's disease

    Author : Axel Abelein; Astrid Gräslund; Adriaan Bax; Stockholms universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Biophysics; biofysik;

    Abstract : Misfolding of proteins and peptides is closely linked to several neurodegenerative disorders, among them Alzheimer's disease (AD), the most prominent example of brain diseases. The self-assembly of the amyloid β peptide (Aβ) into amyloid fibrils is one histologic hallmark of AD. READ MORE

  2. 2. Development of NMR methods for studies of dynamics and structure : applications to motilin, Alzheimer β-peptide and ubiquitin

    Author : Peter Damberg; Ad Bax; USA Maryland National Institutes of Health; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; Biophysics; biofysik;

    Abstract : NMR spin relaxation was used to study structure and dynamics of two biologically important peptides.The first case concerns the three-dimensional structure of the 22 amino acid residue peptide hormone motilin in the presence of SDS micelles, which mimic a biomembrane environment. READ MORE

  3. 3. Insight into the mitochondrial apoptotic pathway : The interplay of the pro-apoptotic Bax protein with oxidized phospholipids and its counterplayer, the pro-survival Bcl-2 protein

    Author : Marcus Wallgren; Gerhard Gröbner; Marco Colombini; Umeå universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; apoptosis; Bax; Bcl-2; CD; cell-free protein synthesis; DSC; membrane; mitochondria; oxidized phospholipids; reconstitution; solid state NMR; biologisk kemi; biological chemistry;

    Abstract : Apoptosis plays a crucial role in multicellular organisms by preserving tissue homeostasis and removing harmful cells. The anti-apoptotic B-cell CLL/lymphoma 2 (Bcl-2) and the pro-apoptotic Bcl-2-associated X protein (Bax) act as major regulators of the mitochondrial apoptotic pathway. READ MORE

  4. 4. Bax and oxidized phospholipids - a deadly complex : Apoptotic protein-lipid assemblies studied by MAS NMR spectroscopy

    Author : Artur Dingeldein; Gerhard Gröbner; Mikael Elofsson; Tobias Sparrman; Daniel Topgaard; Umeå universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; NMR spectroscopy; mitochondrial membranes; apoptosis; membrane dynamics and organization; Bcl-2 family proteins; Bax protein; biokemi; Biochemistry;

    Abstract : Mitochondria are renowned for their vital role as cellular powerhouses because they provide ATP via cellular respiration. Additionally, these organelles also play an important role in other physiological processes, such as apoptosis. READ MORE

  5. 5. Effects of arsenic trioxide and hypoxia in multidrug-resistant neuroblastoma

    Author : Jenny Karlsson; Institutionen för translationell medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Klinisk biologi; Clinical biology; neuroblastoma; multidrug resistance; hypoxia; glucose-deficiency; cell death; Bax; Apoptosis; arsenic trioxide;

    Abstract : Neuroblastoma is a childhood tumour derived from the sympathetic nervous system. Although most children with neuroblastoma initially respond to treatment, approximately 50% of these patients relapse with multidrug-resistant tumours. Arsenic trioxide (As2O3) has been used for centuries to treat different clinical disorders including malignancies. READ MORE