Search for dissertations about: "Bayesian model selection"

Showing result 11 - 15 of 43 swedish dissertations containing the words Bayesian model selection.

2. 11. Dose Adaptation Based on Pharmacometric Models

   Author : Johan Wallin; Mats Karlsson; Lena Friberg; Maria Garrido; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biopharmacy; Biofarmaci; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

   Abstract : Many drugs exhibit major variability in both pharmacokinetic (PK) and pharmacodynamic (PD) parameters that prevents the use of the same dose for all patients. Variability can occur both between patients (IIV) as well as within patients over the course of time (IOV). READ MORE

4. 12. Essays on Bayesian Inference for Social Networks

   Author : Johan Koskinen; Ove Frank; Philippa Pattison; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Bayesian inference; social network analysis; Markov chain Monte Carlo; exponential random graphs; cognitive social structures; longitudinal social networks.; Statistics; Statistik;

   Abstract : This thesis presents Bayesian solutions to inference problems for three types of social network data structures: a single observation of a social network, repeated observations on the same social network, and repeated observations on a social network developing through time.A social network is conceived as being a structure consisting of actors and their social interaction with each other. READ MORE

5. 13. Model-Based Optimization of Clinical Trial Designs

   Author : Camille Vong; Mats O. Karlsson; Andrew C. Hooker; Lena E. Friberg; Marylore Chenel; Oliver Sander; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nonlinear mixed-effects models; pharmacometrics; likelihood ratio test; NONMEM; power; sample size; study design; proof-of-concept; dose-finding; population optimal design; LOQ; BQL data; neutropenia; docetaxel; myelosuppression; thrombocytopenia; MTD; Bayesian methods; 3 3 algorithm; dose escalation study; Pharmaceutical Science; Farmaceutisk vetenskap;

   Abstract : General attrition rates in drug development pipeline have been recognized as a necessity to shift gears towards new methodologies that allow earlier and correct decisions, and the optimal use of all information accrued throughout the process. The quantitative science of pharmacometrics using pharmacokinetic-pharmacodynamic models was identified as one of the strategies core to this renaissance. READ MORE

6. 14. Study Design and Dose Regimen Evaluation of Antibiotics based on Pharmacokinetic and Pharmacodynamic Modelling

   Author : Anders Kristoffersson; Lena Friberg; Mats Karlsson; Pernilla Lagerbäck; Otto Cars; Stephan Schmidt; Uppsala universitet; []
   Keywords : pharmacometric; optimal design; pharmacokinetics; pharmacodynamics; PKPD; resistance; antibiotics; modeling; time-kill curve; colistin; meropenem; ciprofloxacin; non-linear mixed effects models; bayesian; Farmaceutisk vetenskap; Pharmaceutical Science;

   Abstract : Current excessive use and abuse of antibiotics has resulted in increasing bacterial resistance to common treatment options which is threatening to deprive us of a pillar of modern medicine. In this work methods to optimize the use of existing antibiotics and to help development of new antibiotics were developed and applied. READ MORE

7. 15. Phylogenetic Support and Chloroplast Genome Evolution in Sileneae (Caryophyllaceae)

   Author : Per Erixon; Bengt Oxelman; Sean Graham; Uppsala universitet; []
   Keywords : Biology; Phylogenetics; Bayesian inference; Bootstrapping; cpDNA; Sileneae; Interspecific chloroplast recombination; Hybridization; clpP; Positive selection; Extreme substitution rates; Biologi;

   Abstract : Evolutionary biology is dependent on accurate phylogenies. In this thesis two branch support methods, Bayesian posterior probablities and bootstrap frequencies, were evaluated with simulated data and empirical data from the chloroplast genome. READ MORE