Search for dissertations about: "Beta cells"
Showing result 1 - 5 of 629 swedish dissertations containing the words Beta cells.
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1. Auxiliary Cells for the Vascularization and Function of Endogenous and Transplanted Islets of Langerhans
Abstract : Type 1 diabetes develops through the progressive destruction of the insulin-producing beta-cells. Regeneration or replacement of beta-cells is therefore needed to restore normal glucose homeostasis. Presently, normoglycemia can be achieved by the transplantation of whole pancreas or isolated islets of Langerhans. READ MORE
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2. From the pancreatic beta cell to the endothelium:Pathophysiological aspects of Type 2 Diabetes
Abstract : The incidence of Diabetes Mellitus increases globally in epidemic proportions. Type 2 Diabetes is the most prevalent form of Diabetes, comprising 90% of the patients. In Type 2 Diabetes, two processes contribute to the development of the disease: insufficient insulin secretion from the pancreatic ?-cell and insulin resistance of the target organs. READ MORE
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3. Frk/Shb Signalling in Pancreatic Beta-cells : Roles in Islet Function, Beta-cell Development and Survival as Implicated in Mouse Knockout Models
Abstract : The adaptor protein Shb and the non-receptor tyrosine kinase Frk have been implicated in intracellular signalling in insulin-producing beta cells. In this thesis, knockout mice are used to further elucidate the role of Shb and Frk for beta cell number, cytokine-induced cell death, and glucose homeostasis. READ MORE
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4. Cholesterol in T cells : homeostasis, plasma membrane organization and signaling
Abstract : The plasma membrane of eukaryotic cells contains cholesterol and glycosphingolipids enriched nanodomains known as lipid rafts; which are believed to exist in a liquid ordered (lo) state. Methyl-beta-cyclodextrin (MBCD) is used to deplete cellular cholesterol and a widespread assumption is that MBCD preferentially targets cholesterol in lipid rafts. READ MORE
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5. Protein tyrosine kinases in insulin producing cells : Expression and putative importance for beta-cell function
Abstract : Protein tyrosine kinases are of importance for cell replication and differentiation in manysystems. The mechanisms controlling the replication and differentiation of insulin producingcells are unknown. READ MORE