Search for dissertations about: "Biased signalling"

Found 3 swedish dissertations containing the words Biased signalling.

  2. 1. Free Fatty Acid Receptor 2 - A G protein coupled receptor with unique signaling properties in neutrophils

    Author : Simon Lind; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neutrophils; G protein coupled receptors; Free Fatty Acid Receptor 2; GPR43; Allosteric modulation; Transactivation; Cross-talk; Biased signalling; Functional selectivity;

    Abstract : The overall aim of the PhD thesis was to determine the role of neutrophil pattern recognition receptors in the initiation and resolution of inflammatory processes. Neutrophil pattern recognition receptors such as the formyl peptide receptors (FPRs) and the short free fatty acid receptors (FFARs) belong to the family of G protein coupled receptors (GPCR). READ MORE

  4. 2. Biased signalling at the IGF-1R : pitfalls and potential of the GRK/beta-arrestin system in cancer therapeutics

    Author : Caitrin Crudden; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Embedded into the boundary between the living machinery and the external space, plasma membrane receptors allow cells to perceive their environment and elicit appropriate responses. Two of the largest classes of receptors are the G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs). READ MORE

  5. 3. Molecular function and targeting of β-arrestins in cancer

    Author : Huiyuan Zheng; Karolinska Institutet; Karolinska Institutet; []
    Keywords : IGF-1R;

    Abstract : In the selection leading to cancer, cancer cells make use of the normal extracellular signaling to gain a growth advantage over normal cells. These signals are, in part, generated by plasma membrane receptors. G Protein Coupled Receptors (GPCRs) and Receptor Tyrosine Kinases (RTKs) are major transducer of signals across the plasma membrane. READ MORE