Search for dissertations about: "Bioactive Conformation"

Showing result 1 - 5 of 16 swedish dissertations containing the words Bioactive Conformation.

  1. 1. The solution conformations of macrocycles. Applications in the exploration of weak interactions and in drug development

    University dissertation from Göteborgs universitet

    Author : Emma Danelius; Göteborgs universitet.; Gothenburg University.; [2017]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Macrocycles; cyclic peptides; NMR; solution conformational analysis; NAMFIS; β-hairpin; weak interactions; halogen bonding; protein-protein interaction; bioactive conformation; macrolides; cell permeable conformation.;

    Abstract : Understanding the solution conformation and dynamics of molecules with biological relevance, as well as the impact of their conformation stabilizing weak interactions, is for example important for drug design. Macrocycles have attractive pharmaceutical properties, and are of special interest as drug leads for targets with large, flat and featureless binding sites like protein-protein interfaces. READ MORE

  2. 2. A mapping of the interactions between a moth sex pheromone component and its receptor

    University dissertation from Organic Chemistry, Lund University

    Author : Anna-Lena Gustavsson; [1996]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; chiral recognition; bioactive conformation; structure-activity; Agrotis segetum; Z -5-decenyl acetate; pheromone analogues; single-cell electrophysiology; molecular mechanics; ab initio; MM3; quantum mechanical calculations; 3D-QSAR; bioisosteres; Organisk kemi;

    Abstract : Popular Abstract in Swedish Insekter kommunicerar med dofter. De artspecifika kemiska substanser som används mellan individer kallas feromoner. Hos sädesbroddflyet, Agrotis segetum, producerar honan en "parfym", ett sexualferomon som består av flera komponenter, för att locka till sig en hane. READ MORE

  3. 3. Synthesis of Aldehyde-Functionalized Building Blocks and Their Use for the Cyclization of Peptides Applications to Angiotensin II

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Petra Johannesson; Uppsala universitet.; [2002]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; Synthesis; Aldehyde; Cyclization; Peptide; Angiotensin II; Ang II; Bioactive Conformation; Solid Phase Peptide Synthesis; Dimethyl Acetal; Farmaceutisk kemi; Syntes; Aldehyd; Cyklisering; Peptid; Bioaktiv konformation; Fast-fas peptidsyntes; Dimetylacetal; PHARMACY Pharmaceutical chemistry; FARMACI Farmaceutisk kemi; Organic Pharmaceutical Chemistry; organisk farmaceutisk kemi;

    Abstract : This study addresses the issue of how to convert peptides into drug-like non- peptides with retained biological activities at peptide receptors. Angiotensin II (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe, Ang II) was used as a model peptide. READ MORE

  4. 4. Computational Modeling of the AT2 Receptor and AT2 Receptor Ligands Investigating Ligand Binding, Structure–Activity Relationships, and Receptor-Bound Models

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Christian Sköld; Uppsala universitet.; [2007]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; Angiotensin II; AT1; AT2; SAR; bioactive conformation; turn mimetic; peptidomimetic; DISCO; homology model; 3D-QSAR; CoMFA; Farmaceutisk kemi;

    Abstract : Rational conversion of biologically active peptides to nonpeptide compounds with retained activity is an appealing approach in drug development. One important objective of the work presented in this thesis was to use computational modeling to aid in such a conversion of the peptide angiotensin II (Ang II, Asp-Arg-Val-Tyr-Ile-His-Pro-Phe). READ MORE

  5. 5. Design and synthesis of -turn peptidomimetics Applications to angiotensin II

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Susanna Lindman; Uppsala universitet.; [2001]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; peptide synthesis; turn mimetics; molecular modelling; receptor binding affinity; Farmaceutisk kemi; PHARMACY Pharmaceutical chemistry; FARMACI Farmaceutisk kemi; Organic Pharmaceutical Chemistry; organisk farmaceutisk kemi;

    Abstract : This study addresses the issue of how to convert peptides into drug-like non-peptides while retaining the biological activity at peptide receptors. Angiotensin II (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe, Ang II) was used as a model peptide. Small bioactive peptides are in most cases conformationally flexible molecules. READ MORE