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Showing result 1 - 5 of 21 swedish dissertations matching the above criteria.

2. 1. Semicarbazide-sensitive amine oxidase and vascular complications in diabetes mellitus : Biochemical and molecular aspects

   Author : Jenny Nordquist; Keith F. Tipton; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; diabetes; SSAO; VAP-1; retinopathy; methylamine; aminoacetone; hydralazine; Farmakologi; Pharmacological research; Farmakologisk forskning; medicinsk farmakologi; Medical Pharmacology;

   Abstract : Plasma activity of the enzyme semicarbazide-sensitive amine oxidase (SSAO; EC.1.4.3. READ MORE

4. 2. Novel Fatty Acid Dioxygenases of Human and Plant Pathogenic Fungi : Studies by Gene Deletion and Expression

   Author : Fredrik Jernerén; Ernst Oliw; Ivo Feussner; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; aspergilli; dioxygenase; oxygenase; Magnaporthe oryzae; Gaeumannomyces graminis; Lasiodiplodia theobromae; jasmonic acid; linoleate diol synthase; cyclooxygenase; prostaglandin H synthase; cytochrome P450; oxylipin; hydroperoxide isomerase; allene oxide synthase; Pharmaceutical pharmacology; Farmaceutisk farmakologi; Biochemical Pharmacology; Biokemisk farmakologi;

   Abstract : The dioxygenase-cytochrome P450 fusion proteins (DOX-CYP) comprise a heme-containing enzyme family that shares structural and catalytic properties with mammalian prostaglandin H (PGH) synthases. 7,8-Linoleate diol synthase (7,8-LDS) of Gaeumannomyces graminis was first characterized, and DOX-CYP enzymes are of mechanistic and biological interest. READ MORE

5. 3. Mass Spectrometric Analysis of Oxylipins : Application to Cytochrome P450-Dependent Metabolism

   Author : Tomas Nilsson; Ernst Oliw; Johan Bylund; Mikael Hedeland; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; epoxyalcohols; fatty acids; hydroperoxides; electrospray ionization; ichthyosis; CYP4; linear ion trap; fragmentation mechanism; Pharmaceutical pharmacology; Farmaceutisk farmakologi; Biochemical Pharmacology; Biokemisk farmakologi;

   Abstract : Cytochrome P450 (CYP) family 4 constitutes monoxygenases responsible for hydroxylation of fatty acids and other lipids. For example, CYP4F3 metabolizes leukotrienes and CYP4F8 prostaglandin H. Importantly, six of the twelve CYP4 enzymes are orphans, i.e. READ MORE

6. 4. Substance P Endopeptidase : Purification and Characterizataion of Enzyme Activity and Evaluation of its Function during Stressful Condition

   Author : Krister Karlsson; Lars Oreland; Fred Nyberg; Tsukasa Sakurada; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacology; Substance P Endopeptidase; Neuropeptide; Central Nervous System; Purification; Drug Dependence; Heat Stress; Farmakologi; Pharmacological research; Farmakologisk forskning;

   Abstract : The purification and biochemical characterization of the substance P (SP) hydrolyzing enzyme, substance P endopeptidase (SPE), have been carried out; with subsequent orientation in neurobiological fundamental processes involved in opioid dependence, withdrawal, and heat-stress.SPE was purified from rat spinal cord, human spinal cord and cerebrospinal fluid (CSF), rat ventral tegemental area (VTA), and rat hippocampus. READ MORE

7. 5. Cannabinoids as modulators of cancer cell viability, neuronal differentiation, and embryonal development

   Author : Sofia Gustafsson; Stig Jacobsson; Birgitta Sander; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cannabinoids; cell viability; neuronal differentiation; colorectal cancer; chick embryo; biokemisk farmakologi; biochemical pharmacology; Toxicology; toxikologi;

   Abstract : Cannabinoids (CBs) are compounds that activate the CB1 and CB2 receptors. CB receptors mediate many different physiological functions, and cannabinoids have been reported to decrease tumor cell viability, proliferation, migration, as well as to modulate metastasis. READ MORE