Search for dissertations about: "Biofarmaci"
Showing result 16 - 20 of 76 swedish dissertations containing the word Biofarmaci.
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16. Investigation and Prediction of Small Intestinal Precipitation of Poorly Soluble Drugs : a Study Involving in silico, in vitro and in vivo Assessment
Abstract : The main objectives of the present project were to increase the understanding of small intestinal precipitation of poorly soluble pharmaceutical drugs, investigate occurrence of crystalline small intestinal precipitation and effects of precipitation on absorption. The aim was to create and evaluate methods of predicting crystalline small intestinal drug precipitation using in vivo, in vitro and in silico models. READ MORE
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17. Biopharmaceutical aspects of intestinal drug absorption : Regional permeability and absorption-modifying excipients
Abstract : Before an orally administered drug reaches the systemic circulation, it has to dissolve in the intestinal fluids, permeate across the intestinal epithelial cell barrier, and pass through the liver. The permeation rate of drug compounds can be low and show regional differences.The thesis had two general aims. READ MORE
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18. Discovery of N-hydroxyguanidines as novel electron acceptors of xanthine oxidase : Potential new drugs for treatment of ischemia and reperfusion injury
Abstract : Xanthine oxidase (EC 1.1.3.22) is one of the major enzymatic sources of oxygen-derived free radicals. READ MORE
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19. Biopharmaceutical investigations of doxorubicin formulations used in liver cancer treatment : Studies in healthy pigs and liver cancer patients, combined with pharmacokinetic and biopharmaceutical modelling
Abstract : There are currently two types of drug formulation in clinical use in the locoregional treatment of intermediate hepatocellular carcinoma (HCC). In the emulsion LIPDOX, the cytostatic agent doxorubicin (DOX) is dissolved in the aqueous phase, which is emulsified with the oily contrast agent Lipiodol® (LIP). READ MORE
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20. Towards time-resolved molecular interaction assays in living bacteria
Abstract : Rare and neglected diseases such as multidrug resistant (MDR) tuberculosis, malaria and trypanosomiasis are re-emerging in Europe. New strategies are needed to accelerate drug discovery to fight these pathogens. READ MORE