Search for dissertations about: "Biofysikalisk kemi"

Showing result 1 - 5 of 40 swedish dissertations containing the words Biofysikalisk kemi.

  2. 1. 5-Aminolevulinic acid and derivatives thereof : properties, lipid permeability and enzymatic reactions

    Author : Edvin Erdtman; Leif Eriksson; Tore Brinck; Örebro universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; 5-Aminolevulinic acid; tautomerization; PDT; DFT; MM; QM MM; Porphobilinogen synthase; Uroporphyrinogen III decarboxylase; membrane penetration; enzyme mechanism; Biophysical chemistry; Biofysikalisk kemi; Quantum chemistry; Kvantkemi; Theoretical chemistry; Teoretisk kemi; Fysikalisk kemi; Physical Chemistry; Biochemistry; Biokemi;

    Abstract : 5-aminolevulinic acid (5-ALA) and derivatives thereof are widely usedprodrugs in treatment of pre-malignant skin diseases of the cancer treatmentmethod photodynamic therapy (PDT). The target molecule in 5-ALAPDTis protoporphyrin IX (PpIX), which is synthesized endogenously from5-ALA via the heme pathway in the cell. READ MORE

  4. 2. Protein-water interactions studied by molecular dynamics simulations

    Author : Filip Persson; Biofysikalisk kemi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MD simulations; NMR nuclear magnetic resonance ; MRD; water dynamics; protein dynamics; protein hydration; Amide hydrogen exchange; Internal water; compressibility;

    Abstract : Most proteins have evolved to function optimally in aqueous environments, and the interactions between protein and water therefore play a fundamental role in the stability, dynamics, and function of proteins. Although we understand many details of water, we understand much less about the protein-water interface. READ MORE

  5. 3. Computational studies of photodynamic drugs, phototoxic reactions and drug design

    Author : Klefah Abrahem Klefah Musa; Leif Eriksson; Nino Russo; Örebro universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NSAIDs; fluoroquinolone; photodegradation; phototoxicity; drug design; DFT; TD-DFT; Biophysical chemistry; Biofysikalisk kemi; Chemistry; Kemi;

    Abstract : The most important criterion when designing new drugs or improving old ones in order to prevent side effects or at least diminish them is drug safety. Treatment of all diseases generally needs use of either topical application or systemic medications (transported in the blood) during a certain period of time. READ MORE

  6. 4. A theoretical study of 5-Aminolevulinic acid and its esters : properties and lipid permeability

    Author : Edvin Erdtman; Leif Eriksson; Fahmi Himo; Örebro universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biophysical chemistry; Biofysikalisk kemi; fysikalisk kemi; Physical Chemistry;

    Abstract : 5-aminolevulinic acid (5ALA) is a widely used prodrug in Photodynamic therapy (PDT). The target molecule in 5ALA-PDT is Protoporphyrin IX (PpIX), which is synthesized endogenously via the heme pathway in the cell. READ MORE

  7. 5. On the mechanism of Urea-induced protein denaturation

    Author : Matteus Lindgren; Per-Olof Westlund; Arnold Maliniak; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Chemical denaturation; Protein unfolding; urea; MD simulations; NMR spectroscopy; Biophysical chemistry; Biofysikalisk kemi; fysikalisk kemi; Physical Chemistry;

    Abstract : It is well known that folded proteins in water are destabilized by the addition of urea. When a protein loses its ability to perform its biological activity due to a change in its structure, it is said to denaturate. READ MORE