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Showing result 11 - 15 of 635 swedish dissertations matching the above criteria.

2. 11. Formalizing life : Towards an improved understanding of the sequence-structure relationship in alpha-helical transmembrane proteins

   Author : Håkan Viklund; Arne Elofsson; Kimmen Sjölander; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; bioinformatics; protein; topology; hidden Markov model; prediction; Bioinformatics; Bioinformatik; Biochemistry; biokemi;

   Abstract : Genes coding for alpha-helical transmembrane proteins constitute roughly 25% of the total number of genes in a typical organism. As these proteins are vital parts of many biological processes, an improved understanding of them is important for achieving a better understanding of the mechanisms that constitute life. READ MORE

4. 12. Bioinformatic Methods in Metagenomics

   Author : Johannes Alneberg; Anders F. Andersson; Lars Arvestad; Nicola Segata; KTH; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Bioinformatics; Metagenomics; Microbiome; Binning; Baltic Sea; Bioinformatik; Metagenomik; Mikrobiom; Binning; Östersjön;

   Abstract : Microbial organisms are a vital part of our global ecosystem. Yet, our knowledge of them is still lacking. Direct sequencing of microbial communities, i.e. READ MORE

5. 13. Rule-based Models of Transcriptional Regulation and Complex Diseases : Applications and Development

   Author : Susanne Bornelöv; Jan Komorowski; Claes Wadelius; Joanna Polanska; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Histone modification; Transcription factor; Transcriptional regulation; Next-generation sequencing; Feature selection; Machine learning; Rule-based classification; Asthma; Allergy; Bioinformatik; Bioinformatics;

   Abstract : As we gain increased understanding of genetic disorders and gene regulation more focus has turned towards complex interactions. Combinations of genes or gene and environmental factors have been suggested to explain the missing heritability behind complex diseases. READ MORE

6. 14. Computational methods for analysis of fragmented sequence data

   Author : Fredrik Boulund; Göteborgs universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; bioinformatics; metagenomics; proteomics; sequencing; distributed computing; bioinformatics;

   Abstract : Recent developments in genomic and proteomic sequencing technologies have revolutionized research in life sciences, providing new opportunities for the study of biological systems. However, modern sequence data sets are large, diverse, and heavily fragmented, which presents new challenges for their analysis and interpretation. READ MORE

7. 15. Development of Computational Methods for Cancer Research: Strategies for closing the feedback loop in omics workflows

   Author : Ufuk Kirik; Institutionen för immunteknologi; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; cancer; proteome profiling; bioinformatics; pathway analysis; mass spectrometry; Quantitative proteomics;

   Abstract : As the ultimate workhorses of the living things, proteins undergo significant regulatory activity throughout the lifetime of a cell or an organism. Many complex diseases effect the protein composition, expression or modification in the cells or tissues they arise in. READ MORE