Search for dissertations about: "Bioinformatics"
Showing result 36 - 40 of 635 swedish dissertations containing the word Bioinformatics.
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36. Integrating multi-omics for type 2 diabetes : Data science and big data towards personalized medicine
Abstract : Type 2 diabetes (T2D) is a complex metabolic disease characterized by multi-tissue insulin resistance and failure of the pancreatic β-cells to secrete sufficient amounts of insulin. Cells recruit transcription factors (TF) to specific genomic loci to regulate gene expression that consequently affects the protein and metabolite abundancies. READ MORE
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37. Domain rearrangement and creation in protein evolution
Abstract : Proteins are composed of domains, recurrent protein fragments with distinct structure, function and evolutionary history. Some domains exist only as single domain proteins, however, a majority of them are also combined with other domains. READ MORE
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38. Towards Individualized Drug Dosage : General Methods and Case Studies
Abstract : Progress in individualized drug treatment is of increasing importance, promising to avoid much human suffering and reducing medical treatment costs for society. The strategy is to maximize the therapeutic effects and minimize the negative side effects of a drug on individual or group basis. READ MORE
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39. Towards an Earlier Detection of Progressive Multiple Sclerosis using Metabolomics and Machine Learning
Abstract : Decision-making guided by advanced analytics is becoming increasingly common in many fields. Implementing computationally driven healthcare solutions does, however, pose ethical dilemmas as it involves human health. READ MORE
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40. Structure-based Virtual Screening for Ligands of G Protein-coupled Receptors : Design of Allosteric and Dual-Target Modulators
Abstract : G protein-coupled receptors (GPCRs) are integral membrane proteins responsible for signal transduction of extracellular stimuli into the cell. Because of their widespread distribution throughout the human body and important roles in physiological processes, GPCRs are prominent drug targets and approximately 34% of all approved drugs interact with members of this superfamily. READ MORE