Search for dissertations about: "Biologi med inriktning mot molekylär bioteknik"

Showing result 1 - 5 of 17 swedish dissertations containing the words Biologi med inriktning mot molekylär bioteknik.

  1. 1. Adenovirus for Cancer Therapy With a Focus on its Surface Modification

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Di Yu; Uppsala universitet.; [2013]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Adenovirus; cancer; therapy; neuroblastoma; neuroendocrine; modification; Tat; PTD; cell penetrating peptide; Helicobacter pylori; NAP; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi; Klinisk virologi; Clinical Virology; Medical Virology; Medicinsk virologi; Molekylär medicin; Molecular Medicine; Molekylär bioteknik; Molecular Biotechnology;

    Abstract : Adenovirus serotype 5 (Ad5) is widely used as an oncolytic agent for cancer therapy. However, its infectivity is highly dependent on the expression level of coxsackievirus-adenovirus receptor (CAR) on the surface of tumor cells. READ MORE

  2. 2. Structure-function studies on TRIM21/Ro52, a protein involved in autoimmune diseases

    University dissertation from Linköping : Linköping University Electronic Press

    Author : Janosch Hennig; Linköpings universitet.; Linköpings universitet.; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICINE Chemistry Biochemistry; MEDICIN Kemi Biokemi;

    Abstract : Several members of the tripartite motif (TRIM) protein family are involvedin antiviral activity and immunity and have been linked to severaldiseases. TRIM21, the main object of this thesis, is involved in Sjögrensyndrome (SS) and systemic lupus erythematosus (SLE), where patientsoften have autoantibodies against different epitopes on TRIM21. READ MORE

  3. 3. Novel Culture Strategies and Signal Transduction Pathways of Pluripotent Stem Cells

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Sara Pijuan Galitó; Uppsala universitet.; [2015]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pluripotent stem cells; Inter-alpha inhibitor; culture method; Biologi med inriktning mot molekylär cellbiologi; Biology with specialization in Molecular Cell Biology; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

    Abstract : Pluripotent stem cells (PSCs) can self-renew indefinitely in culture while maintaining their capacity to differentiate into any cell type of an organism, thus offering novel sources for drug screening, in vitro disease modelling, and cell replacement therapies. However, due to their sensitive nature, many PSC lines are still cultured using undefined components such as serum or serum-derived components, on either feeder cells or complex protein mixes such as Matrigel or gelatine. READ MORE

  4. 4. DNA-Assisted Immunoassays for High-Performance Protein Analyses

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Junhong Yan; Uppsala universitet.; Uppsala universitet.; [2014]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; proximity ligation assay; magnetic beads; conjugation; phosphorylation; affinity binder; protein complexes; recombinant binder; sensitivity; specificity; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

    Abstract : Proteins play important roles in most cellular functions, such as, replication, transcription regulation, signal transduction, for catalyzing chemical reaction, etc. Technologies developed to identify proteins rely either on observing their own properties such as charge, size, mass to charge ratio or sequence composition; or on using affinity reagents that recognize specific protein targets. READ MORE

  5. 5. Calculations of Reaction Mechanisms and Entropic Effects in Enzyme Catalysis

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Masoud Kazemi; Uppsala universitet.; Uppsala universitet.; [2017]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Enzyme catalysis; Entropy; Cytidine deamination; Ribosome; Peptidyl-tRNA hydrolysis; Peptide bond formation; Empirical valence bond method; Density functional theory; Biology with specialization in Structural Biology; Biologi med inriktning mot strukturbiologi; Biokemi; Biochemistry; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

    Abstract : Ground state destabilization is a hypothesis to explain enzyme catalysis. The most popular interpretation of it is the entropic effect, which states that enzymes accelerate biochemical reactions by bringing the reactants to a favorable position and orientation and the entropy cost of this is compensated by enthalpy of binding. READ MORE