Search for dissertations about: "Biologi med inriktning mot molekylär bioteknik"

Showing result 11 - 15 of 25 swedish dissertations containing the words Biologi med inriktning mot molekylär bioteknik.

2. 11. Biological Insights from Single-Particle Tracking in Living Cells

   Author : Arash Sanamrad; Johan Elf; Måns Ehrenberg; Achillefs Kapanidis; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; single-particle tracking; intracellular diffusion; nucleoid exclusion; transcription-translation coupling; antibiotics; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

   Abstract : Single-particle tracking is a technique that allows for quantitative analysis of the localization and movement of particles. In this technique, trajectories are constructed by determining and connecting the positions of individual particles from consecutive images. READ MORE

4. 12. Mechanisms and Inhibition of EF-G-dependent Translocation and Recycling of the Bacterial Ribosome

   Author : Anneli Borg; Måns Ehrenberg; Ruben Gonzalez; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Protein synthesis; Elongation factor G; Translocation; Ribosome recycling; Fusidic acid; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

   Abstract : The GTPase elongation factor G (EF-G) is an important player in the complex process of protein synthesis by bacterial ribosomes. Although extensively studied much remains to be learned about this fascinating protein. READ MORE

5. 13. Solid-phase Proximity Ligation Assays : High-performance and multiplex protein analyses

   Author : Spyros Darmanis; Masood Kamali-Moghaddam; Ulf Landegren; Mathias Uhlen; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; proximity ligation assay; multiplexed; biomarkers; solid-phase; microparticles; cancer; sequencing; Molecular biology; Molekylärbiologi; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

   Abstract : Protein biomarkers circulating in blood hold the promise of improved diagnosis, prognosis and follow-up of treatment of disease via minimally invasive procedures. For the discovery and validation of such biomarkers, methods are needed that can facilitate parallel, highly specific and in-depth analysis of the blood proteome. READ MORE

6. 14. Free energy calculations of G protein-coupled receptor modulation : New methods and applications

   Author : Willem Jespers; Hugo Gutiérrez-de-Terán; Johan Åqvist; Jonathan Essex; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; G protein-coupled receptor; adenosine receptor; molecular dynamics; free energy perturbation; homology modeling; computer simulations; conformational selectivity; binding free energy.; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

   Abstract : G protein-coupled receptors (GPCRs) are membrane proteins that transduce the signals of extracellular ligands, such as hormones, neurotransmitters and metabolites, through an intracellular response via G proteins. They are abundant in human physiology and approximately 34% of the marketed drugs target a GPCR. READ MORE

7. 15. Rate and Accuracy of Bacterial Protein Synthesis

   Author : Magnus Johansson; Måns Ehrenberg; Jon Lorsch; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; protein synthesis; ribosome; peptidyl transfer; rate-accuracy trade-off; kinetics; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

   Abstract : High levels of accuracy in transcription, aminoacylation of tRNA, and mRNA translation are essential for all life forms. However, high accuracy also necessarily means large energy dissipation and slow kinetics. Therefore, in vivo there is a fine tuned balance between rate and accuracy of key chemical reactions. READ MORE