Search for dissertations about: "Biologi med inriktning mot molekylär cellbiologi"
Showing result 11 - 15 of 22 swedish dissertations containing the words Biologi med inriktning mot molekylär cellbiologi.
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11. Regulation of TGF-β Signaling by Post-Translational Modifications
Abstract : Transforming growth factor-β (TGF-β) signaling is initiated when the ligand binds to type II and type I serine/threonine kinase receptors at the cell surface. Activated TGF-β type I receptors phosphorylate R-Smads which relocate, together with co-Smads, to the cell nucleus and regulate transcription. READ MORE
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12. Adhesion Dependent Signals : Cell Survival, Receptor Crosstalk and Mechanostimulation
Abstract : The integrin family of cell surface receptors is evolutionary conserved and found in all multicellular animals. In humans 8-alpha and 18-beta integrins are non-covalently associated into 24 dimers. Integrins mediate cell-extracellular matrix and cell-cell interactions and participate in cell signalling. READ MORE
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13. Novel Culture Strategies and Signal Transduction Pathways of Pluripotent Stem Cells
Abstract : Pluripotent stem cells (PSCs) can self-renew indefinitely in culture while maintaining their capacity to differentiate into any cell type of an organism, thus offering novel sources for drug screening, in vitro disease modelling, and cell replacement therapies. However, due to their sensitive nature, many PSC lines are still cultured using undefined components such as serum or serum-derived components, on either feeder cells or complex protein mixes such as Matrigel or gelatine. READ MORE
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14. Membrane lipids and their transfer proteins in β-cells
Abstract : Insulin secretion from β-cells is essential for glucose homeostasis and is often dysregulated in diabetes. Intracellular Ca2+ and membrane lipids cooperate to control insulin secretion with high spatial and temporal precision. READ MORE
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15. Regulation and Function of MAP Kinases in PDGF Signaling
Abstract : Platelet-derived growth factor (PDGF) is a family of signaling molecules that stimulates cell growth, survival and migration. PDGF is recognized by specific transmembrane proteins, the PDGF receptors, which relay the signals to the cell activating the Mitogen-activated protein (MAP) kinases and other signaling pathways. READ MORE