Search for dissertations about: "Biologi med inriktning mot molekylärbiologi"

Showing result 31 - 35 of 96 swedish dissertations containing the words Biologi med inriktning mot molekylärbiologi.

  2. 31. Calculations of Reaction Mechanisms and Entropic Effects in Enzyme Catalysis

    Author : Masoud Kazemi; Johan Åqvist; Per E. M. Siegbahn; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Enzyme catalysis; Entropy; Cytidine deamination; Ribosome; Peptidyl-tRNA hydrolysis; Peptide bond formation; Empirical valence bond method; Density functional theory; Biology with specialization in Structural Biology; Biologi med inriktning mot strukturbiologi; Biokemi; Biochemistry; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

    Abstract : Ground state destabilization is a hypothesis to explain enzyme catalysis. The most popular interpretation of it is the entropic effect, which states that enzymes accelerate biochemical reactions by bringing the reactants to a favorable position and orientation and the entropy cost of this is compensated by enthalpy of binding. READ MORE

  4. 32. Ribosomal translocation in real time : Method development to Applications

    Author : Chang-il Kim; Suparna Sanyal; Martin Ott; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; ribosome; EF-G; pyrene mRNA; aminoglycoside; ribosomal protein; GTP hydrolysis; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

    Abstract : Translational elongation is the process in which the ribosome adds one amino acid at a time to the nascent peptide chain. As the ribosome elongates the peptide chain by 14 - 20 amino acids per second and performs hundreds of such cycles per protein, ‘elongation’ is one of the most crucial steps in translation. READ MORE

  5. 33. Investigation of RNase P active site residues and catalytic domain interaction

    Author : Guanzhong Mao; Leif Kirsebom; Roland Hartmann; Britt-marie Sjöberg; Anders Byström; Anthony Forster; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; RNase P; Ribozyme; PRORP; Induced fit model; RNase P-pre-tRNA interaction; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

    Abstract : RNase P is an essential endoribonuclease responsible for the maturation of the tRNA 5’end. The RNase P family encompasses the ribozyme based, RNase P RNP, and proteinaceous RNase P (PRORP). The ribozyme based RNase P is widely distributed in most species while PRORP has so far mainly been found in some eukaryotic cells. READ MORE

  6. 34. Novel insights into protist diversity and niche adaptation using single cell transcriptomics

    Author : Henning Onsbring; Thijs J. G. Ettema; Alastair Simpson; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Protists; microbial eukaryotes; cultivation-independent methods; single-cell RNA sequencing; phylogenomics; Biologi med inriktning mot molekylär evolution; Biology with specialization in Molecular Evolution;

    Abstract : Protists are a polyphyletic group of microbes that represents the vast majority of eukaryotic diversity. Despite this, most sequencing efforts targeting eukaryotes have been focused on animals, fungi and plants. READ MORE

  7. 35. Protein Folding Activity of the Ribosome and Its Implication in Prion Processes

    Author : Yanhong Pang; Suparna Sanyal; Patricia L. Clark; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Ribosome; Protein folding; Prion disease; Antiprion drug; Competitive inhibition; PFAR; Amyloid; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

    Abstract : How the linear protein chains fold into their three-dimensional active conformation is one of the remaining puzzles of modern science. Other than molecular chaperones, ribosome - the cellular protein synthesis machinery, has also been implicated in protein folding. READ MORE