Search for dissertations about: "Biologi med inriktning mot strukturbiologi"
Showing result 11 - 15 of 23 swedish dissertations containing the words Biologi med inriktning mot strukturbiologi.
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11. Small Particles with Big Impact : Structural Studies of Viruses and Toxicological Studies of Nanodiamonds
Abstract : Nanoparticles (NPs) can be found everywhere and their existence has both beneficial and harmful consequences for the environment and living beings. The investigations on which this thesis is based upon have contributed to an increased understanding of some of these particles and to the development of a method that could be used to study their structure. READ MORE
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12. Structural Studies of Large dsDNA Viruses using Single Particle Methods
Abstract : Structural studies of large biological assemblies pose a unique problem due to their size, complexity and heterogeneity. Conventional methods like x-ray crystallography, NMR, etc. are limited in their ability to address these issues. To overcome some of these limitations, single particle methods were used. READ MORE
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13. Molecular mechanisms underlying the activation of ALC1 nucleosome remodeling
Abstract : Packaging DNA into chromatin represses essential DNA-based processes, such as transcription, DNA replication, and repair. To change the accessibility of DNA, cells have evolved a set of enzymes referred to as chromatin remodelers that act on the basic repeat unit of chromatin, the nucleosome. READ MORE
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14. Structural and Biochemical Studies of Antibiotic Resistance and Ribosomal Frameshifting
Abstract : Protein synthesis, translation, performed by the ribosome, is a fundamental process of life and one of the main targets of antibacterial drugs. This thesis provides structural and biochemical understanding of three aspects of bacterial translation.Elongation factor G (EF-G) is the target for the antibiotic fusidic acid (FA). READ MORE
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15. New Paradigms in GPCR Drug Discovery : Structure Prediction and Design of Ligands with Tailored Properties
Abstract : G protein-coupled receptors (GPCRs) constitute a large superfamily of membrane proteins with key roles in cellular signaling. Upon activation by a ligand, GPCRs transduce signals from the extracellular to the intracellular environment. READ MORE