Search for dissertations about: "Biology with specialization in Structural Biology"

Showing result 1 - 5 of 32 swedish dissertations containing the words Biology with specialization in Structural Biology.

  1. 1. Evolutionary and Pharmacological Studies of NPY and QRFP Receptors

    University dissertation from Uppsala, Sweden : Acta Universitatis Upsaliensis

    Author : Bo Xu; Uppsala universitet.; [2014]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Neuropeptide Y; genome duplication; Evolution; vertebrate; Pharmacology; Modelling; Kinetics; Bioinformatik; Bioinformatics; Biology with specialization in Evolutionary Genetics; Biologi med inriktning mot evolutionär genetik; Biologi med inriktning mot evolutionär funktionsgenomik; Biology with specialization in Evolutionary Functional Genomics; Farmaceutisk farmakologi; Pharmaceutical Pharmacology;

    Abstract : The neuropeptide Y (NPY) system consists of 3-4 peptides and 4-7 receptors in vertebrates. It has powerful effects on appetite regulation and is involved in many other biological processes including blood pressure regulation, bone formation and anxiety. READ MORE

  2. 2. Targeting Infectious Disease Structural and functional studies of proteins from two RNA viruses and Mycobacterium tuberculosis

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Anna M. Jansson; Uppsala universitet.; [2013]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; RNA virus; coronavirus; alphacoronavirus; nsp1; TGEV; flavivirus; Modoc virus; NS5; methyltransferase; mRNA capping; Mycobacterium tuberculosis; tuberculosis; 1-deoxy-D-xylulose 5-phosphate reductoisomerase; DXR; fosmidomycin analogues; MEP pathway; drug development; xray-crystallography; Biology with specialization in Structural Biology; Biologi med inriktning mot strukturbiologi; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi; Biokemi; Biochemistry; Medicinal Chemistry; Läkemedelskemi;

    Abstract : The recent emergence of a number of new viral diseases as well as the re-emergence of tuberculosis (TB), indicate an urgent need for new drugs against viral and bacterial infections.Coronavirus nsp1 has been shown to induce suppression of host gene expression and interfere with host immune response. READ MORE

  3. 3. Of spiders, bugs, and men Structural and functional studies of proteins involved in assembly

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Wangshu Jiang; Uppsala universitet.; [2018]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Protein assembly; sulfate transporter; crystallography; Proteus mirabilis; fimbriae; adhesin; urinary tract infection; biofilm; spider silk; asymmetric dimer; Bri2; BRICHOS; molecular chaperone; Alzheimer s disease; amyloid; Biology with specialization in Structural Biology; Biologi med inriktning mot strukturbiologi;

    Abstract : Protein assembly enables complex machineries while being economical with genetic information. However, protein assembly also constitutes a potential threat to the host, and needs to be carefully regulated.Sulfate is a common source of sulfur for cysteine synthesis in bacteria. READ MORE

  4. 4. Ribosomal RNA Modification Enzymes Structural and functional studies of two methyltransferases for 23S rRNA modification in Escherichia coli

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Avinash S. Punekar; Uppsala universitet.; [2014]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Escherichia coli; ribosome biogenesis; ribosome assembly; ribosomal RNA; peptidyltransferase center; domain V; post-transcriptional modification; methyltransferases; S-adenosyl-methionine; RlmM; Cm2498; RlmJ; m6A2030; X-ray crystallography; substrate recognition; substrate specificity; catalytic mechanism; evolution; Biology with specialization in Structural Biology; Biologi med inriktning mot strukturbiologi; Biokemi; Biochemistry;

    Abstract : Escherichia coli ribosomal RNA (rRNA) is post-transcriptionally modified by site-specific enzymes. The role of most modifications is not known and little is known about how these enzymes recognize their target substrates. READ MORE

  5. 5. Structural and Biochemical Studies of Antibiotic Resistance and Ribosomal Frameshifting

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Yang Chen; Uppsala universitet.; [2013]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; protein synthesis; elongation; elongation factor G; fusidic acid; antibiotic resistance; aminoglycoside adenyltransferase; ribosomal frameshifting; Biology with specialization in Structural Biology; Biologi med inriktning mot strukturbiologi;

    Abstract : Protein synthesis, translation, performed by the ribosome, is a fundamental process of life and one of the main targets of antibacterial drugs. This thesis provides structural and biochemical understanding of three aspects of bacterial translation.Elongation factor G (EF-G) is the target for the antibiotic fusidic acid (FA). READ MORE