Search for dissertations about: "Biomarkör"

Showing result 6 - 10 of 35 swedish dissertations containing the word Biomarkör.

  2. 6. Aggrecan fragments as biomarkers in osteoarthritis

    Author : Staffan Larsson; Lund Ortopedi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; protease; Aggrecan; osteoarthritis; proteoglycan; knee injury; biomarker; aggrecanase;

    Abstract : Background: In osteoarthritis (OA) the balance of cartilage matrix synthesis and degradation is disturbed, resulting in a gradual destruction of the articular cartilage. Matrix components released into body fluids by proteolytic cleavage can be used as biomarkers of ongoing processes. READ MORE

  4. 7. Prospective and longitudinal human studies of lead and cadmium exposure and the kidney

    Author : Johan Nilsson Sommar; Ingvar A Bergdahl; Max Petzold; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cadmium; end-stage renal disease; kidney; lead; longitudinal; matched case-control; mixed effects; prospective; Occupational and Environmental Medicine; arbets- och miljömedicin;

    Abstract : Cadmium and lead accumulate in humans and can have toxic effects. Exposure to cadmium is well known to cause kidney damage. Cadmium binds to metallothioneins, proteins that play a role in cadmium transport. READ MORE

  5. 8. Utility of novel drug targets for treatment of metastatic cancer

    Author : Tianyan Wang; Jenny Persson; Thomas Grundström; Maréne Landström; Margareta Wilhelm; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Metastatic cancer; castration-resistant prostate cancer; pancreatic ductal adenocarcinoma; target therapy; PIP5K1α; KRAS; molecularly imprinted polymers; Oncology; onkologi; molekylärbiologi; Molecular Biology; Medical Cell Biology; medicinsk cellbiologi;

    Abstract : Metastasis is the leading cause of cancer death because of a lack of early diagnosis tools and efficient treatment drugs. The lipid kinase phosphatidylinositol 4-phosphate 5 kinase (PIP5K1α) has been shown to play a vital role in the PI3K/AKT and KRAS signaling pathways. READ MORE

  6. 9. Modeling environment effects on spectroscopic properties of biomarkers and catalytic mechanisms in enzymes

    Author : Camilla Gustafsson; Patrick Norman; Daniel Escudero; KTH; []
    Keywords : Computational chemistry; spectroscopy; biocatalysis; water flow; biomarkers; Teoretisk kemi och biologi; Theoretical Chemistry and Biology;

    Abstract : Arguably, humans are in need of both better diagnostic tools to prevent pro- gression of diseases as well as greener catalysts for synthesis of chemicals.Neurodegenerative diseases affecting neurons in the brain leads to demen- tias, where Alzheimer’s disease (AD) is the most prevalent. READ MORE

  7. 10. Studies on Heparin Binding protein in bacterial infections

    Author : Adam Linder; Infektionsmedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Infectious diseases remain a major health problem, where sepsis and other severe bacterial infections are common causes of morbidity and mortality, and are associated with high costs for the community. The importance of early and appropriate treatment of sepsis and severe bacterial infections has been underlined by many and since sepsis is more prevalent and has a higher mortality rate than for instance acute myocardial infarction, there is a need for improvement. READ MORE