Search for dissertations about: "Biomedicine"

Showing result 1 - 5 of 109 swedish dissertations containing the word Biomedicine.

  1. 1. Inflammasome polymorphisms and the Inflammatory Response to Bacterial Infections

    Author : Berhane Asfaw Idosa; Eva Särndahl; Anne Kelly; Bo Söderquist; Alexander Persson; Johan Bylund; Örebro universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bacteremia; Cytokines; Gene variants; Inflammasome; Inflammation; Innate immunity; Neutrophils; Meningitis; Neisseria meningitidis; Biomedicin; Biomedicine;

    Abstract : NLRP3 inflammasome; a key component of the innate immune system, can be activated by a number of pathogens and other threats of the body. Activation of the NLRP3 inflammasome triggers caspase-1 mediated maturationof IL-1β and IL-18. READ MORE

  2. 2. Molecular mechanisms mediating development of pulmonary cachexia in COPD

    Author : Vladimir Basic; Jorge Ruas; Örebro universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; COPD; cachexia; atrophy; cigarette smoke; myogenesis; angiogenesis; Biomedicin; Biomedicine; Biokemi; Biochemistry;

    Abstract : Cigarette smoking (CS) represents the main causative agent underlying development and progress of COPD. Recently, involvement of CS in the pathogenesis of COPDassociated muscle abnormalities is becoming increasingly evident. Nevertheless, involved triggers and underlying mechanisms remain largely unknown. READ MORE

  3. 3. Tumor Cell Targeting of Stabilized Liposome Conjugates : Experimental studies using boronated DNA-binding agents

    Author : Erika Bohl Kullberg; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedicine; Liposome; EGF; HER-2; Targeting; boron; Biomedicin; Microbiology; Mikrobiologi; Biomedical Radiation Science; biomedicinsk strålningsvetenskap;

    Abstract : To further develop cancer therapy, targeted delivery of cell killing agents directly to tumor cells is an interesting approach. This thesis describes the development of PEG-stabilized liposome conjugates targeting either epidermal growth factor receptor (EGFR) using its natural ligand EGF, or human epidermal growth factor receptor 2 (HER-2) using the antibody trastuzumab. READ MORE

  4. 4. Genetic variation in the folate receptor-alpha and methylenetetrahydrofolate reductase genes as determinants of plasma homocysteine concentrations

    Author : Anna Böttiger; Torbjörn Nilsson; Henrik Zetterberg; Örebro universitet; []
    Keywords : LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; Folate receptor-alpha; Folate; FOLR1; Haplotypes; Homocysteine; Methylenetetrahydrofolate reductase; MTHFR; Polymorphisms; Pyrosequencing®; SSCP; Medicine; Medicin; Biomedicin; Biomedicine;

    Abstract : Elevated total plasma homocysteine (tHcy) is a risk factor for cardiovascular disease and neurocognitive disease such as dementia. The B vitamins folate and B12 are the main de terminants of tHcy. tHcy concentration can also be affected by mutations in genes coding for receptors, enzymes and transporters important in the metabolism of Hcy. READ MORE

  5. 5. Uropathogenic Esherichia coli, multidrug-resistance and induction of host defense mechanisms

    Author : Isak Demirel; Katarina Persson; Robert Kruse; Mirjana Poljakovic; Gabriela Godaly; Örebro universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Urinary tract infection; uropathogenic Escherichia coli; suppressor of cytokine signalling 3; nitric oxide; cytokines; extended-spectrum beta-lactamases; filamentation; IL-6; Biomedicin; Biomedicine;

    Abstract : Uropathogenic Escherichia coli (UPEC) is the primary cause of urinary tract infection (UTI), which is one of the most common infections in humans. UPEC strains have acquired successful strategies to subvert the host defense and antibiotics to persist in the urinary tract. READ MORE