Search for dissertations about: "Bioorganic chemistry"

Showing result 6 - 10 of 30 swedish dissertations containing the words Bioorganic chemistry.

2. 6. Discovery-Oriented Screening of Dynamic Systems: Combinatorial and Synthetic Applications

   Author : Marcus Angelin; Olof Ramström; Stefan Kubik; KTH; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; chemical education; crystallization; dynamic combinatorial chemistry; dynamic combinatorial resolution; dynamic system; enzyme catalysis; isoindolinone; lipase; nitroalcohol; nitroaldol reaction; phthalide; reversible; secondary alcohol; systems chemistry; tandem reaction; Organic chemistry; Organisk kemi; Bioorganic chemistry; Bioorganisk kemi;

   Abstract : This thesis is divided into six parts, all centered around the development of dynamic (i.e., reversibly interacting) systems of molecules and their applications in dynamic combinatorial chemistry (DCC) and organic synthesis. READ MORE

4. 7. A Chemical Approach Toward the Therapeutic Optimization of Cytotoxic Bioconjugates

   Author : Rafael Hartmann; Luke R. Odell; Fredrik Lehmann; Mats Larhed; Dario Neri; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Chemotherapy; antibody-drug conjugates; organic synthesis; bioorganic chemistry; synthetic method development; analytical method development; Chemistry with specialization in Bioorganic Chemistry; Kemi med inriktning mot bioorganisk kemi; Medicinal Chemistry; Läkemedelskemi; Chemistry with specialization in Organic Chemistry; Kemi med inriktning mot organisk kemi;

   Abstract : The delivery of cytotoxicity to specific cells was recognized to be the key to the effective, chemical treatment of infectious and neoplastic diseases well over a century ago. In the context of oncology, the primary therapeutic challenge is the distinction between healthy and pathological cells despite their pronounced pheno- and genotypic similarity. READ MORE

5. 8. Some Aspects of Nucleic Acids Chemistry

   Author : Edouard Zamaratski; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Bioorganic chemistry; Bioorganisk kemi; Bioorganic chemistry; Bioorganisk kemi; bioorganisk kemi; Biorganic Chemistry;

   Abstract : This thesis is divided into two parts based on a total of 8 papers: Part 1: Synthesis, physicochemical and biochemical studies of chemically modified oligonucleotides and their duplexes and triplexes. Potency of the chromophore conjugated DNA oligonucleotides as antigene and antisense gene repressors was evaluated. READ MORE

6. 9. Modified Glycopeptides Targeting Rheumatoid Arthritis : Exploring molecular interactions in class II MHC/glycopeptide/T-cell receptor complexes

   Author : Ida E. Andersson; Jan Kihlberg; Anna Linusson Jonsson; Craig Crews; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Major histocompatibility complex; class II MHC; T-cell receptor; rheumatoid arthritis; collagen-induced arthritis; glycopeptide; amide bond isostere; comparative modeling; rational design; molecular docking; molecular dynamics simulation; statistical molecular design; Bioorganic chemistry; Bioorganisk kemi; organisk kemi; Organic Chemistry; Biorganic Chemistry; bioorganisk kemi; datorlingvistik; computational linguistics;

   Abstract : Rheumatoid arthritis (RA) is an autoimmune inflammatory disease that leads to degradation of cartilage and bone mainly in peripheral joints. In collagen-induced arthritis (CIA), a mouse model for RA, activation of autoimmune CD4+ T cells depends on a molecular recognition system where T-cell receptors (TCRs) recognize a complex between the class II MHC Aq protein and CII259-273, a glycopeptide epitope from type II collagen (CII). READ MORE

7. 10. Aspects of Antisense and Antigene Chemistry of Oligonucleotides Tethered to Intercalators

   Author : Dimitri Ossipov; Jesper Wengel; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Bioorganic chemistry; oligonucleotides; intercalators; ruthenium complexes; RNase H cleavage; photocross-linkage; Bioorganisk kemi; Bioorganic chemistry; Bioorganisk kemi; bioorganisk kemi; Biorganic Chemistry;

   Abstract : Synthetic and physicochemical studies on appropriately functionalized ODN-conjugates have been performed to evaluate their abilities to act as antisense agents against RNA or as intramolecular DNA cross-linking agents. Intercalating aromatic systems [phenazine (Pnz), dipyridophenazine (DPPZ)] and metallointercalators such as Ru2+(phen)2(DPPZ) and Ru2+(tpy)(DPPZ)L [where L = chemically or photochemically labile ligand, phen = phenanthroline, tpy = terpyridine], which are covalently tethered to the oligo-deoxynucleotides (ODNs), have been chosen for this purpose. READ MORE