Search for dissertations about: "Bioorganisk kemi."

Showing result 16 - 20 of 29 swedish dissertations containing the words Bioorganisk kemi..

2. 16. Peptide Conjugates as Useful Molecular Tools

   Author : Adam T. Ślósarczyk; Lars Baltzer; Knud J. Jensen; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; peptide conjugates; designed peptides; polypeptides; molecular recognition; linker; linking technology; bioconjugation; conjugation; conjugates; Kemi; Chemistry; Chemistry with specialization in Bioorganic Chemistry; Kemi med inriktning mot bioorganisk kemi;

   Abstract : The conjugation of a small organic molecule to synthetic polypeptides from a designed set has been shown to give rise to binders with high affinity and selectivity for the phosphorylated model proteins α-casein and β-casein but not for ovoalbumin. The small organic molecule that was used for this purpose is comprised of two di-(2-picolyl)amine groups assembled on a dimethylphenyl scaffold, and is capable of complexing two Zn2+ ions to form chelates that bind the phosphate ion. READ MORE

4. 17. Glycoconjugates : synthesis and investigation of carbohydrate-protein interactions

   Author : Sara Spjut; Mikael Elofsson; Ulf Ellervik; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Glycoconjugates; Carbohydrates; Galactose; Glucose; Solid-phase synthesis; SPOS; Glycosylation; Gel-phase 19F NMR spectroscopy; Fluorinated linker; Carbohydrate array; Microtiter plates; Carbohydrate-protein interactions; carbamate linker; Fsec; Protecting group; Fluorinated protecting group; Multivalent glycoconjugates; Adenovirus; Ad37; Epidemic keratoconjunctivitis; EKC; Sialic acid; Adenovirus inhibitor; Trivalent; Tetravalent; X-ray crystal structure; Bioorganic chemistry; Bioorganisk kemi; organisk kemi; Organic Chemistry;

   Abstract : To study the functions of glycoconjugates in biological systems reliable and efficient protocols for glycoconjugate synthesis are needed. To reach this goal we have developed methods for solid-phase synthesis of glycoconjugates that can be monitored with gel-phase 19F spectroscopy using fluorinated linkers, building blocks, and protecting groups. READ MORE

5. 18. Synthesis and investigation of bacterial effector molecules

   Author : Michael Franz Albers; Christian Hedberg; Christian Hackenberger; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; bacterial effectors; organic synthesis; Legionella; PTM; peptide synthesis; nucleotide chemistry; Biorganic Chemistry; bioorganisk kemi;

   Abstract : During infections, bacterial microorganisms initiate profound interactions with mammalian host cells. Usually defense mechanisms of the host destroy intruding bacteria in rapid manner. However, many bacterial pathogens have evolved in a way to avoid these mechanisms. READ MORE

6. 19. Statistical molecular design, QSAR modeling, and scaffold hopping – Development of type III secretion inhibitors in Gram negative bacteria

   Author : Markus Dahlgren; Mikael Elofsson; Bo Nordén; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Statistical molecular design; QSAR; synthesis; type III secretion; virulence; scaffold hopping; Bioorganic chemistry; Bioorganisk kemi; datorlingvistik; computational linguistics;

   Abstract : Type III secretion is a virulence system utilized by several clinically important Gram-negative pathogens. Computational methods have been used to develop two classes of type III secretion inhibitors, the salicylidene acylhydrazides and the acetylated salicylanilides. READ MORE

7. 20. Design and Synthesis of Sialic Acid Conjugates as Inhibitors of EKC-causing Adenoviruses

   Author : Susanne Johansson; Jan Kihlberg; Mikael Elofsson; Stefan Oscarson; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Sialic acid; sialylmimetics; sialylation; multivalency; glycoconjugates; adenovirus; antiviral agents; epidemic keratoconjunctivitis; Bioorganic chemistry; Bioorganisk kemi;

   Abstract : The combat against viral diseases has been, and still is, a major challenge in the field of drug development. Viruses are intracellular parasites that use the host cell ma-chinery for their replication and release. Therefore it is difficult to target and destroy the viral particle without disturbing the essential functions of the host cell. READ MORE