Search for dissertations about: "Biopharmaceutical"

Showing result 1 - 5 of 34 swedish dissertations containing the word Biopharmaceutical.

  2. 1. China's Creation of Biopharmaceutical Drugs : Combining Political Steering, Military Research, and Transnational Networking

    Author : Åse Linné; Alexandra Waluszewski; Enrico Baraldi; David Ford; Uppsala universitet; []
    Keywords : SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; innovation; biotechnology; China; resource interfaces; commerciali-zation; Chinese government; command network economy; biopharmaceutical drugs; military research;

    Abstract : Not only the Western world is focused on creating new innovations based on scientific discoveries; this is also the case in China where discoveries in biotechnology science are aimed at creating new biopharmaceutical drugs in order to create a future biotechnology industry and in the end generate economic growth. The focus to invest in high-tech industries such as biotechnology can be traced to the “open-door policy” issued in 1978 with the aim to modernize China and transform China into a “socialistic market economy. READ MORE

  4. 2. Systems Analysis of the Protein Secretory Pathway in Yeast and Human Cells

    Author : Amir Feizi; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; protein production; flux balance analysis; biopharmaceutical; secretory pathway: secretome; recombinant protein; genome-scale modeling; systems biology;

    Abstract : The cell was discovered by Robert Hooke in 1665, later in nineteen century the cell theory was developed as all organisms are composed of one or more cells. Since then, many tools and experimental methods have been developed to dissect and characterize the cell components which resulted in established solid scientific fields such as biochemistry, molecular cell biology and genetics. READ MORE

  5. 3. Biopharmaceutical investigations of doxorubicin formulations used in liver cancer treatment : Studies in healthy pigs and liver cancer patients, combined with pharmacokinetic and biopharmaceutical modelling

    Author : Ilse R Dubbelboer; Hans Lennernäs; Erik Sjögren; Hartmut Derendorf; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; drug delivery system; in vivo release; PBPK modelling; hepatocellular carcinoma; doxorubicin; transarterial chemoembolization; drug disposition; Biofarmaci; Biopharmaceutics; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : There are currently two types of drug formulation in clinical use in the locoregional treatment of intermediate hepatocellular carcinoma (HCC). In the emulsion LIPDOX, the cytostatic agent doxorubicin (DOX) is dissolved in the aqueous phase, which is emulsified with the oily contrast agent Lipiodol® (LIP). READ MORE

  6. 4. Biopharmaceutical aspects of intestinal drug absorption : Regional permeability and absorption-modifying excipients

    Author : David Dahlgren; Hans Lennernäs; Erik Sjögren; Bertil Abrahamsson; Christer Tannergren; Steffansen Bente; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; intestinal permeability; absorption-modifying excipients; Biofarmaci; Biopharmaceutics;

    Abstract : Before an orally administered drug reaches the systemic circulation, it has to dissolve in the intestinal fluids, permeate across the intestinal epithelial cell barrier, and pass through the liver. The permeation rate of drug compounds can be low and show regional differences.The thesis had two general aims. READ MORE

  7. 5. Monitoring of product variants in biopharmaceutical downstream processing : Mechanistic and data-driven modeling approaches

    Author : Patricia Roch; Carl-Fredrik Mandenius; Gunnar Hörnsten; Franciscus van der Berg; Linköpings universitet; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY;

    Abstract : During the manufacturing of biopharmaceuticals, a multistep purification strategy is employed to remove process-related impurities and product variants, to achieve high product quality, assuring patients’ safety. To guarantee that biopharmaceuticals are safe and to accomplish quality, strict policies were established by regulatory agencies as well as guiding principles, such as Quality by Design and process analytical technology. READ MORE