Advanced search

Showing result 1 - 5 of 7 swedish dissertations matching the above criteria.

  2. 1. Evolution and Binding Mechanisms of Intrinsically Disordered Proteins

    Author : Elin Karlsson; Per Jemth; Kaare Teilum; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Intrinsically disordered proteins; Protein evolution; Binding kinetics; Binding mechanisms; Biophysical characterisation; Medicinsk biokemi; Medical Biochemistry;

    Abstract : Intrinsically disordered proteins (IDPs) make up a considerable fraction of the proteome in eukaryotic organisms. These proteins often act as hubs in interaction networks, harbouring multiple interaction with other proteins, and thus evolution has to walk a tightrope to accommodate new interactions while maintaining the previously established interactions. READ MORE

  4. 2. Biophysical Characterisation of Macromolecules. Protein Folding and DNA Structure Determination

    Author : Cecilia Engman; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : .... READ MORE

  5. 3. Antibody-Fragments: Protein Engineering, Process Development, and their Application as Affinity Ligands

    Author : Laila Sakhnini; Tillämpad biokemi; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Monoclonal Antibodies; Aggregation; Biophysical Characterisation; Process Development; Affinity Adsorbents; Monoclonal Antibodies; Aggregation; Biophysical Characterisation; Process Development; Affinity Adsorbents;

    Abstract : Monoclonal antibody (mAb) fragments have become the formats of choice for both biopharmaceuticals and ligands in analytical and preparative applications. Their smaller size enables additional advantages over full-length mAbs, such as improved tissue penetration, faster blood clearance for diagnostic applications, improved capacity, and enablement of multivalent formatting. READ MORE

  6. 4. Apoptosis Regulation via the Mitochondrial Pathway : Membrane Response upon Apoptotic Stimuli

    Author : Marc-Antoine Sani; Gerhard Grobner; Antoinette Killian; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Apoptosis; BH4 peptide; Bax-α1 peptide; model membrane; cardiolipin; solid phase peptide synthesis; circular dichroism; solid-state nuclear magnetic resonance spectroscopy.; Biophysics; Biofysik;

    Abstract : The aim of this thesis was the investigation of the mitochondrial response mechanisms upon apoptotic stimuli. The specific objectives were the biophysical characterization of membrane dynamics and the specific roles of lipids in the context of apoptotic regulation occurring at the mitochondrion and its complex membrane systems. READ MORE

  7. 5. From cell populations to single cells - quantitative analysis of osmotic regulation in yeast

    Author : Elzbieta Petelenz; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; mikrobiologi; systembiologi;

    Abstract : To date, interdisciplinary research is becoming increasingly popular because it combines the achievements of diverse disciplines, having the potential of providing a completely new angle to pertinent research problems. Using increasingly sophisticated tools allowed obtaining large sets of high resolution data but also created the challenge of using this information effectively and interpreting it in a reliable way. READ MORE