Search for dissertations about: "Biophysical chemistry"
Showing result 11 - 15 of 47 swedish dissertations containing the words Biophysical chemistry.
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11. Biophysical chemistry of the ALS-associated protein SOD1 : Implications for folding, aggregation and in-cell behaviour
Abstract : Biophysical chemistry deals with the structural behavior, properties and molecular function of biological macromolecules. A long-standing challenge is here to establish how these macromolecular features change upon transfer from simplified conditions in vitro to the crowded and molecularly complex environment of live cells. READ MORE
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12. The sweet side of molecular structure : NMR spectroscopic studies of glycans and their interactions with proteins
Abstract : In this thesis, within the topic of bioorganic chemistry, the molecular structure of carbohydrates has been studied. Carbohydrates, or glycans, are ubiquitous biomolecules exhibiting a wide range of biological roles. READ MORE
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13. Membrane mediated aggregation of amyloid-β protein : a potential key event in Alzheimer's disease
Abstract : The pathogenesis of Alzheimer’s disease (AD), the most common senile dementia, is a complex process. A crucial event in AD is the aggregation of amyloid-β protein (Aβ), a cleavage product from the Amyloid Precursor Protein (APP). READ MORE
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14. Protein structure dynamics and interplay : by single-particle electron microscopy
Abstract : Single-particle cryo-electron microscopy (cryo-EM) is a method capable of obtaining information about the structural organization and dynamics of large macromolecular assemblies. In the late nineties, the method was suggested to have the potential of generating “atomic resolution” reconstructions of particles above a certain mass. READ MORE
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15. Into the Membrane and Beyond : Improving Membrane Protein Over-Expression in Escherichia coli
Abstract : Membrane proteins fulfil a wide variety of essential functions in the cell and many are (potential) drug targets. Since their natural abundance is usually very low, most membrane proteins have to be over-expressed for functional and structural studies. READ MORE