Search for dissertations about: "Bioplex"
Found 5 swedish dissertations containing the word Bioplex.
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1. The development of synthetic gene delivery systems
Abstract : This thesis describes a new platform technology. The technique is referred to as Bioplex (biological complex) in analogy with the nomenclature for other transfection reagents, since we attach biological functions to a nucleic acid complex via sequence-specific hybridisation. READ MORE
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2. DNA analogs for the purpose of gene therapy
Abstract : This thesis describes DNA analogs and their potential use for gene therapeutic purposes, primarily by sequence specific strand-invasion of double-stranded DNA. Gene therapy is classically thought of as restoration of a defect gene. READ MORE
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3. Immune responses against Mycobacterium tuberculosis targets associated to latent and active tuberculosis infection
Abstract : Background: Tuberculosis is a worldwide problem particularly in developing countries. Different clinical outcomes, such as the asymptomatic phase during infection or the symptomatic stage during active disease leads to activation and expansion of cellular immune responses in order to control the infection. READ MORE
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4. Development of nonviral gene delivery and of anti-gene reagents
Abstract : Although significant progress has been made in the basic science and applications of various non-viral gene delivery systems, the majority of non-viral approaches are still much less efficient than viral vectors, especially for in vivo gene delivery, Therefore, non-viral gene delivery must be developed in order to increase the efficiency of in vivo delivery. Moreover, a novel anti-gene reagent was developed for sequence-specific gene silencing. READ MORE
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5. Development of novel DNA vaccine and immunotherapeutic approaches
Abstract : Many potential DNA vaccination and immunotherapeutic strategies has been explored in both animal models and human settings in recent years. However, the failure of efficient and safe method development suggests that it is time to rethink, since more innovative approaches are needed for better control of infection and immunotherapy. READ MORE
