Search for dissertations about: "Biotransformation"

Showing result 21 - 25 of 55 swedish dissertations containing the word Biotransformation.

  2. 21. An integrated approach to study pharmaceuticals and their microbial transformation products: formation and environmental behavior in water/sediment systems

    Author : Zhe Li; Michael Radke; Anna Sobek; Magnus Åberg; Urs Berger; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Applied Environmental Science; tillämpad miljövetenskap;

    Abstract : Pharmaceuticals are emerging organic micropollutants that are frequently detected in the aquatic environment. While information on their environmental occurrence is substantial, knowledge gaps exist with respect to their environmental transformation. READ MORE

  4. 22. Evolution and Ecology of AhR genes in Atlantic salmon (Salmo salar L.)

    Author : Maria Hansson; Biodiversitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; AhR genes; Atlantic salmon; gene evolution; phylogenetics; environmental pollutants; Baltic Sea; ecotoxicology; Animal ecology; Djurekologi;

    Abstract : In vertebrates, studies of the aryl hydrocarbon receptor (AhR) have been of particular interest due to its direct involvement in the toxic effects exerted by several environmental pollutants, such as PCB and dioxin. After binding to the toxic molecule, this receptor initiates transcription of several genes that are part of the biotransformation battery but most notably the cytochrome P450 (CYP) genes, which results in an excessive release of oxidative enzymes and free radicals. READ MORE

  5. 23. Remediation of TNT-contaminated water by using industrial low-cost residue pine bark

    Author : Olga Chusova; Emma Nehrenheim; Monica Odlare; Jaquiline Akhavan; Mälardalens högskola; []
    Keywords : Energy- and Environmental Engineering; energi- och miljöteknik;

    Abstract : In the process of demilitarization of explosives, army ammunition plants generate a waste stream known as pink water. The principal component of the wastewater is the nitro-aromatic compound 2,4,6-trinitrotoluene (TNT). READ MORE

  6. 24. Chemical transformation of the anticancer drug oxaliplatin

    Author : Elin Jerremalm; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Oxaliplatin is a new platinum based cytostatic drug. It is used in combination with 5-fluorouracil and leucovorin, both as palliative and adjuvant treatment of metastatic colorectal cancer. Various biotransformation products are formed non-enzymatically after oxaliplatin administration. READ MORE

  7. 25. Gene expression in buccal keratinocytes with emphasis on carbonyl metabolism

    Author : Claudia A Staab; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The inner lining of the cheek, the buccal mucosa, is a target for air-borne, dietary and tobacco usage-derived carcinogens, but also interesting from a drug delivery point of view. Cancer arising in the buccal epithelium, buccal squamous cell carcinoma (BSCC), often diagnosed at a late disease stage, is highly aggressive and recurrent, emphasizing the need for novel approaches in diagnosis and therapy. READ MORE