Search for dissertations about: "Bo Stenerlöw"

Showing result 1 - 5 of 13 swedish dissertations containing the words Bo Stenerlöw.

  1. 1. Biological effects of accelerated ions : analysis of cell survival and DNA double-strand breaks in cultured cells

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Bo Stenerlöw; [1995]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURAL SCIENCES; NATURVETENSKAP;

    Abstract : .... READ MORE

  2. 2. Induction and repair of clustered DNA damage sites after exposure to ionizing radiation

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Andris Abramenkovs; Bo Stenerlöw; Peter O'Neill; [2019]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NHEJ; DSB repair; clustered DNA damage; DNA repair; DNA-PKcs; HSCS; Ra-223; ionizing radiation; Medicinsk vetenskap; Medical Science;

    Abstract : The mechanisms that maintain genomic stability safeguard cells from constant DNA damage produced by endogenous and external stressors. Therefore, this thesis aimed to specifically address questions regarding the requirement and involvement of DNA repair proteins in the repair of various types of radiation-induced DNA damage. READ MORE

  3. 3. Studies of DNA repair strategies in response to complex DNA damages

    University dissertation from Department of Genetics, Microbiology and Toxicology, Stockholm University

    Author : Ainars Bajinskis; Mats Harms-Ringdahl; Bo Stenerlöw; [2012]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; ionizing radiation; complex DNA damage; indirect effect of radiation; dimethyl sulfoxide; molekylärgenetik; Molecular Genetics;

    Abstract : The main aim of this thesis was to study the role of the indirect actions of γ-rays and α-particles on the complexity of primary DNA damages and the repair fidelity of major DNA repair pathways: non-homologous end joining (NHEJ), homologous recombination repair (HRR) and base excision repair (BER). The complexity of radiation-induced damages increases and the proximity between damages decreases with increasing LET due to formation of ionization clusters along the particle track. READ MORE

  4. 4. Radiation response in human cells DNA damage formation, repair and signaling

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Ann-Sofie Gustafsson; Bo Stenerlöw; Andrzej Wojcik; [2015]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; DNA damage; DNA repair; DSB; NHEJ; DNA-PK; ionizing radiation; heat-labile sites; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap;

    Abstract : Ionizing radiation induces a range of different DNA lesions. In terms of mutation frequency and mammalian cell survival, the most critical of these lesions is the DNA double-strand break (DSB). DSB left unrepaired or mis-repaired may result in chromosomal aberrations that can lead to permanent genetic changes or cell death. READ MORE

  5. 5. Colorectal cancer and radiation response The role of EGFR, AKT and cancer stem cell markers

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Sara Häggblad Sahlberg; Bo Stenerlöw; Bengt Glimelius; Marika Nestor; Torgny Stigbrand; [2014]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; colorectal cancer; radiation; AKT; EGFR; cancer stem cells; CD133; CD44; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap; Biologi med inriktning mot molekylär cellbiologi; Biology with specialization in Molecular Cell Biology;

    Abstract : The primary treatment for colorectal cancer is surgery. Radiotherapy and chemotherapy, sometimes combined, are also frequently used to diminish recurrence risk. In response to radiation exposure, several cellular signaling cascades are activated to repair DNA breaks, prevent apoptosis and to keep the cells proliferating. READ MORE