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Showing result 1 - 5 of 11 swedish dissertations matching the above criteria.

  2. 1. Heparan sulfate dependent cell signaling and associated pathophysiology : Implications in tumorigenesis and embryogenesis

    Author : Tahira Batool; Jin-Ping Li; Aristidis Moustakas; Liliana Schaefer; Ingvar Ferby; Michael Welsh; Anders Malmström; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Heparanase; Glucuronyl-C5 epimerase; Heparan Sulfate; Heparin; Lung Cancer; Cancer cell Singling; TGF-Beta; BMP; VEGF; Notch Signaling; Tumor growth; Metastasis; embryonic development; Medical Biochemistry; Medicinsk biokemi;

    Abstract : Heparan sulfate proteoglycans (HSPGs) consist of a protein core to which several linear, negatively charged heparan sulfate (HS) chains are covalently attached. HSPGs are expressed on the cell surface and in the extra-cellular matrix (ECM) where they have diverse biological functions, for example co-receptor functions. READ MORE

  4. 2. Risk factors for falls and fractures in elderly women. The Malmö OPRA study

    Author : Paul Gerdhem; Ortopedi - klinisk och molekylär osteoporosforskning; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Fysiologi; Physiology; muskelsystem; Skelett; muscle system; Skeleton; Falls.; Vitamin D; Bone turnover markers; Frail elderly; Body weight; Physical activity; Osteoporosis; Fractures; Bone density; reumatologi; rheumatology locomotion;

    Abstract : Approximately half of all women will sustain a fracture after the age of 50. Fractures may cause long-term disability and excess mortality. Identifying individuals at high risk of sustaining a fracture is important in the development of primary and secondary prevention strategies. READ MORE

  5. 3. Thyroid hormone receptors and the regulation of bone physiology

    Author : Jenny Kindblom; Göteborgs universitet; []
    Keywords : ;

    Abstract : The aim of the studies in this thesis was to investigate the role of thyroid hormone receptors in bone physiology. Thyroid hormone signals through its receptors, the TRs, and has profound effects on bone development and metabolism, as demonstrated in hypo- and hyperthyroidism. READ MORE

  6. 4. Roles of Androgens in Cardiovascular Physiology and Pathophysiology

    Author : Elin Svedlund Eriksson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; androgens; androgen receptor; atherosclerosis; myocardial infarction; immune system; SARMs; male mice;

    Abstract : ABSTRACT Atherosclerosis is the major underlying cause of cardiovascular disease, such as myocardial infarction (MI) and stroke, and these conditions are the leading causes of death both in Sweden and globally. The immune system is involved in the pathogenesis of atherosclerosis as well as post-MI cardiac injury. READ MORE

  7. 5. The role of autophagy in cartilage physiology and metabolism : implications for growth and ageing

    Author : Karuna Kumari Vuppalapati; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cartilage is the main constituent of the embryonic skeleton. At the ends of long bones cartilage forms a growth plate consisting of chondrocytes in distinct stages of differentiation and arranged into three zones. These chondrocytes mediate linear bone growth through synchronized proliferation, differentiation, and production of matrix. READ MORE