Search for dissertations about: "Bone Development: physiology"

Showing result 6 - 10 of 11 swedish dissertations containing the words Bone Development: physiology.

2. 6. Parathyroid hormone-related protein (PTHrP), calcium and human osteoblast-like cells

   Author : Jon A Tsai; Karolinska Institutet; Karolinska Institutet; []
   Keywords : hOB cells; PTHrP; cAMP; IGFs; IGFBPs; IL-1ß; TGF-ß; [Ca 2 ]i; [Ca2 ]O;

   Abstract : Parathyroid hormone-related protein (PTHrP) may cause humoral hypercalcernia of malignancy (HHM) when overproduced by malignant tumors, but is also produced in lower amounts under normophysiological conditions in practically all cell types, including osteoblasts. One of the aims of the present study was to investigate interactions between PTHrP and osteoblasts, to elucidate bone-regulating functions of PTHrP. READ MORE

4. 7. Mesenchymal stromal cells in lung tissue

   Author : Sara Rolandsson Enes; Lungbiologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mesenchymal stromal cells; lung transplantation; bronchiolitis obliterans syndrome; obliterative bronchiolitis; extracellular matrix;

   Abstract : Mesenchymal stromal cells (MSC) are multipotent cells with immunomodulatory and regenerative properties. During recent years, the interest in using MSC for clinical approaches for various diseases have increased. READ MORE

5. 8. Innate lymphoid cells and cholesterol metabolism in intestinal barrier function

   Author : Sara Martina Parigi; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The intestinal mucosa represents one of the largest barrier sites of our body, having to withstand a constant exposure to a plethora of environmental insults (including dietary compounds, xenobiotics, metabolites and microorganisms). While our body has evolved tolerance/ignorance towards some of these factors deemed beneficial for the host, it requires constant maintenance of epithelial barrier integrity and ability to mount pro-inflammatory responses to protect against potentially harmful environmental insults. READ MORE

6. 9. Cross-regulation between TGFβ/BMP Signalling and the metabolic LKB1 pathway

   Author : Erna Raja; Aristidis Moustakas; Tomi Mäkelä; Uppsala University Faculty of Medicine Ludwig Institute for Cancer Research; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; cell signalling; TGFbeta; BMP; LKB1; AMPK; Molekylär cellbiologi; Molecular Cellbiology;

   Abstract : Cell signalling determines physiological responses to many cellular stimuli and environmental changes. The transforming growth factor-beta (TGFβ)/bone morphogenetic protein (BMP) signalling pathways begin by binding of ligand to the heterodimeric receptor complex, followed by activation of Smads that translocate to the nucleus to regulate transcription of genes that further mediate cellular physiology. READ MORE

7. 10. Cellular and molecular mechanisms of inflammatory arthritis and fibromyalgia

   Author : Carlos Eduardo Morado Urbina; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : In Study I, we examined the impact of the hR100E-NGF mutation on inflammatory pain and bone erosion in both female and male mice. Our findings indicate that the hR100E-NGF mutation did not affect the development of the peripheral sensory nervous system at the lumbar DRG, sciatic nerve, ankle joint, or glabrous skin. READ MORE