Search for dissertations about: "Bone chemotherapy"

Showing result 1 - 5 of 65 swedish dissertations containing the words Bone chemotherapy.

2. 1. Individually Tailored Toxicity-based Chemotherapy : Studies on Patients with Primary and Metastatic Breast Cancer

   Author : Henrik Lindman; Jonas Bergh; Carl Blomqvist; Peter Nygren; Bo Nordenskjöld; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; breast cancer; tailored chemotherapy; toxicity-based dosing; high-dose therapy; MR imaging; G-CSF; epirubicin; docetaxel; cyclophosphamide; 5-fluorouracil; Onkologi; Oncology; Onkologi;

   Abstract : Standard dosing of chemotherapy based on body surface area (BSA) results in large individual differences in toxicity due to a large inter-patient variability in pharmacokinetics (PK) and pharmacodynamics (PD). This results in under-dosing in certain patients with a potentially weaker antitumoral effect. READ MORE

4. 2. Functions and memory features of adaptive- and innate immune cells in physiological and inflammatory settings

   Author : Gintare Lasaviciute; Eva Sverremark-Ekström; Silke Appel; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Innate immune memory; Limosilactobacillus reuteri; dendritic cells; lymphocytes; cytokines; immunological memory; intestinal epithelial cells; chemotherapy; bone marrow; secondary lymphoid organs; molekylär biovetenskap; Molecular Bioscience;

   Abstract : The immune system is a complex but well-regulated network which cooperates with the microbiota to maintain optimal homeostasis under physiological settings. A number of factors display the capacity to alter the immune system and thus microbiota crosstalk including host genetics, diet, environmental influences and drugs such as antibiotics or chemotherapeutic agents. READ MORE

5. 3. Molecular heterogeneity of prostate cancer bone metastasis

   Author : Erik Bovinder Ylitalo; Pernilla Wikström; Anders Bergh; Maria Brattsand; Vessela Kristensen; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; CRPC; castration-resistant; androgen receptor; splice variant; abiraterone; cabazitaxel; ABCB1; cholesterol; Mdr1; P-gp; bone metastasis; immune response; metabolism; osteoblast; osteoclast; BMP; methylation;

   Abstract : Castration-resistant prostate cancer (CRPC) develops after androgen deprivation therapy of advanced PC, often with metastatic growth in bone. Patients with metastatic CRPC have very poor prognosis. Growth of CRPC, in most but not all patients, seems to involve androgen receptor (AR) activity, despite castrate levels of serum testosterone. READ MORE

6. 4. Diagnosis and evaluation of therapeutic response of bone metastases

   Author : Ipek Çiray; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Bone metastases; breast neoplasm; MR imaging; CT; diagnosis; therapy evaluation; Onkologi; Oncology; Onkologi; diagnostisk radiologi; Diagnostic Radiology;

   Abstract : The aim of this study was to investigate different aspects of different imaging modalities in the diagnosis of bone metastases and in the assessment of their response to therapy. The role of CT, with and without clinical information, was investigated as compared to CT-guided bone biopsy in the evaluation of suspected bone metastases. READ MORE

7. 5. On the biological response to different biomaterials under normal and irradiated conditions

   Author : Louise Rydén; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; biomaterials; bone; fibrosis; hydroxyapatite; inflammation; irradiation; Osseointegration; silicone; soft tissue; titanium;

   Abstract : There are several challenges when introducing an implant into a host. Concerning soft tissues, major complications are fibrosis and capsule contracture, whereas for bone, failure of osseointegration may occur. READ MORE