Search for dissertations about: "Bortezomib"

Showing result 11 - 15 of 30 swedish dissertations containing the word Bortezomib.

  2. 11. Analyses of Dose-Response and Mechanistic Action of Different Anti-Cancer Drugs for Neuroendocrine Tumor Cell Lines

    Author : Dhana E Larsson; Dan Granberg; Sadia Hassan; Kjell Öberg; Jens F Rehfeld; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer drugs; Screening; Hollow Fiber model; Apoptosis; Oncology; Onkologi;

    Abstract : Cancer is a disease with poor response rates on available treatments. Problems with resistance and intolerance against cancer drugs are major reasons for failure of the drugs. The need to discover new cancer drugs is important. In this thesis screening of new cancer drugs and evaluation of their mechanism of action are discussed. READ MORE

  4. 12. Inhibition of 19S proteasome deubiquitinases as a promising strategy in cancer therapy

    Author : Magdalena Mazurkiewicz; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The ubiquitin proteasome system (UPS) is the main degradation system in the eukaryotic cell and it is involved in the regulation of many crucial cellular pathways; such as signal transduction, proliferation, DNA repair, cell death, and cell cycle regulation. In comparison to cells in healthy tissues, cancer cells proliferate faster and have increased protein synthesis rate; therefore in order to preserve cellular fitness they are more dependent on UPS than normal cells. READ MORE

  5. 13. Prognostic Biomarkers and Target Proteins for Treatment of High-grade Gliomas

    Author : Linda Sooman; Simon Ekman; Johan Lennartsson; Joachim Gullbo; Michael Bergqvist; Erik Blomquist; Stefan Bergström; Beatrice Melin; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; High-grade glioma; prognostic biomarkers; combination chemotherapy; DNA methylation; FGF2; p38 MAPK; PTPN6; camptothecin; imatinib; vandetanib; EGFR; RAC1; Notch; Medical Science; Medicinsk vetenskap; Oncology; Onkologi;

    Abstract : The survival for high-grade glioma patients is poor and the treatment may cause severe side effects. A common obstacle in the treatment is chemoresistance. To improve the quality of life and prolong survival for these patients prognostic biomarkers and new approaches for chemotherapy are needed. READ MORE

  6. 14. Characterization of malignant pleural mesothelioma : possibilities for an individualized therapeutic arsenal

    Author : Adam Szulkin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Less than 50% of malignant mesothelioma patients respond to standard chemotherapy treatment and there is a great need to identify these patients, and find their best treatment options. The aim of this thesis was to increase the understanding of drug sensitivity in malignant pleural mesothelioma. READ MORE

  7. 15. Studies of overcoming acquired resistance : molecular mechanisms and development of novel drugs

    Author : Xin Wang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Chemotherapeutic agents have become widely applied for treatment of various types of malignancies. Drug resistance unfortunately remains as a major obstacle for the effectiveness of chemotherapy. Cancer drug resistance includes two broad categories: intrinsic and acquired. READ MORE