Search for dissertations about: "Bortezomib"

Showing result 21 - 25 of 30 swedish dissertations containing the word Bortezomib.

  2. 21. Analysis of PDGF receptor internalization and signaling using proximity ligation assays

    Author : Marie Rubin Sander; Ola Söderberg; Cristina Al-Khalili Szigyarto; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PDGFRβ; dynamin; proteolytic cleavage; signaling; internalization; protein-protein interaction; short linear motif; viral hijack; in situ PLA; Molboolean;

    Abstract : Cell signaling is mediated by signaling proteins that relay the signal in an intricate network of interactions before the signal is translated into a biological response. Short linear motifs (SLiMs) in intrinsically disordered regions of proteins serve as docking sites for protein interaction in all aspects of cell regulation including signal transduction. READ MORE

  4. 22. Modulation of PDGF receptors function by posttranslational modifications

    Author : Kehuan Wang; Carl-Henrik Heldin; Johan Lennartsson; Natalia Papadopoulos; Jean-Baptiste Demoulin; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PDGF signaling; receptor tyrosine kinase; ubiquitination; DUB; STAT3; SUMO; SUMOylation; cleavage; autophagy; SQSTM1 p62; LC3; GABARAP; bafilomycin A1; Medicinsk biokemi; Medical Biochemistry; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : The platelet-derived growth factor receptors (PDGFRs) play important roles in multiple cellular processes including cell survival, cell growth and cell migration. Dysregulation of PDGFRs causes aberrant PDGF signaling, which leads to various diseases. READ MORE

  5. 23. Different approaches to develop radio- and chemotherapy for treatment of human cancer

    Author : Chitralekha Mohanty; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Despite huge advancements in our knowledge and understanding of the molecular mechanisms of carcinogenesis, the prognoses of many malignant diseases have not improved dramatically. Improvements in the therapeutic efficacy of several anti-cancer therapies including radiotherapy and chemotherapy would be required to achieve effective treatment. READ MORE

  6. 24. Translational readthrough of nonsense mutant TP53, RB1 and PTEN tumor suppressor genes as a strategy for novel cancer therapy

    Author : Mireia Palomar Siles; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : A nonsense mutation causes a premature termination codon in the coding sequence of an mRNA. This leads to termination of translation and release of a truncated and in most cases non-functional protein. READ MORE

  7. 25. Studies on the mechanisms of sorafenib-induced cell death

    Author : Pedram Kharaziha; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : In 2008, 26% of all deaths were cancer-related, making this group of diseases the second leading cause of death in the EU countries. Derailment of tyrosine kinase signaling is one important pre-requisite towards tumorigenesis. READ MORE