Search for dissertations about: "Bradykinin B1"

Showing result 1 - 5 of 8 swedish dissertations containing the words Bradykinin B1.

  2. 1. G protein-coupled receptor regulation: The role of protein interactions and receptor trafficking

    Author : Caroline Sandén; Drug Target Discovery; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; receptor trafficking; B1 receptor; receptor oligomerization; estrogen; GPER1; G protein-coupled estrogen receptor 1; EP24.15; BK; bradykinin; B1R; B2R; B2 receptor; GPCR; receptor maturation;

    Abstract : The superfamily of G protein-coupled receptors (GPCR) is the largest gene family in the human genome. GPCR-mediated signaling operates in every human cell, and about 50% of existing clinically useful drugs act through GPCR. READ MORE

  4. 2. Cytokine induced airway hyperreactivity characterized in an in-vitro model of asthma

    Author : Yaping Zhang; Klinisk och experimentell allergiforskning; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; toxicology; Farmakologi; farmakognosi; MAPK; TNF-alpha; 5-HT; Respiratory system; Andningsorganen; Pharmacological sciences; pharmacognosy; pharmacy; interleukin-1beta; hyperresponsiveness; endothelin-1; airway; bradykinin; toxikologi; farmaci;

    Abstract : Asthma is a chronic disorder of the lower airways, characterized by inflammation and hyperreactivity. Pro-inflammatory cytokines like tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) are known to play important roles in the pathogenesis, but our knowledge how these cytokines contribute to the development of airway hyperreactivity is limited. READ MORE

  5. 3. Effects of Inflammatory Mediators on Pulmonary Airways

    Author : Ofir Bachar; Klinisk och experimentell allergiforskning; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; electric ?eld stimulation; bradykinin; airway; tumor necrosis factor a; Respiratory system; nitric oxide; Andningsorganen; Toll-like receptor; prostaglandin E2; neurotrophin; allergy;

    Abstract : Chronic inflammation is together with excessive contraction of the airways key features of asthma. The aims of the thesis were to analyze the effect of inflammatory mediators on airway smooth muscle, using an in vitro model of cultured murine airways. READ MORE

  6. 4. Evolution and Pharmacology of Receptors for Bradykinin and Neuropeptide Y in Vertebrates

    Author : Torun Bromée; dan larhammar; Nina Mohell; Samuel Svensson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Pharmacology; Evolution; Neurovetenskap; Neurology; Neurologi;

    Abstract : The bradykinin and neuropeptide Y (NPY) receptors belong to the superfamily of G-protein coupled receptors (GPCRs). The GPCRs form the largest class of therapeutic targets and it is therefore of great interest to investigate the pharmacological properties, functions and evolution of these receptors. READ MORE

  7. 5. Kinin System Activation in Vasculitis

    Author : Robin Kahn; Lund Pediatrik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; kinin receptors; inflammation; vasculitis; proteinase 3; neutophils; anti-neutrophil-cytoplasmic antibodies; Kinin;

    Abstract : The kinin system is activated when high-molecular-weight kininogen (HK) is cleaved by plasma kallikrein thus generating bradykinin. Bradykinin is a potent proinflammatory peptide that induces plasma leakage, blood pressure drop, liberation of inflammatory cytokines and pain. READ MORE