Search for dissertations about: "Bradykinin B1"
Showing result 1 - 5 of 8 swedish dissertations containing the words Bradykinin B1.
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1. G protein-coupled receptor regulation: The role of protein interactions and receptor trafficking
Abstract : The superfamily of G protein-coupled receptors (GPCR) is the largest gene family in the human genome. GPCR-mediated signaling operates in every human cell, and about 50% of existing clinically useful drugs act through GPCR. READ MORE
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2. Cytokine induced airway hyperreactivity characterized in an in-vitro model of asthma
Abstract : Asthma is a chronic disorder of the lower airways, characterized by inflammation and hyperreactivity. Pro-inflammatory cytokines like tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) are known to play important roles in the pathogenesis, but our knowledge how these cytokines contribute to the development of airway hyperreactivity is limited. READ MORE
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3. Effects of Inflammatory Mediators on Pulmonary Airways
Abstract : Chronic inflammation is together with excessive contraction of the airways key features of asthma. The aims of the thesis were to analyze the effect of inflammatory mediators on airway smooth muscle, using an in vitro model of cultured murine airways. READ MORE
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4. Evolution and Pharmacology of Receptors for Bradykinin and Neuropeptide Y in Vertebrates
Abstract : The bradykinin and neuropeptide Y (NPY) receptors belong to the superfamily of G-protein coupled receptors (GPCRs). The GPCRs form the largest class of therapeutic targets and it is therefore of great interest to investigate the pharmacological properties, functions and evolution of these receptors. READ MORE
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5. Kinin System Activation in Vasculitis
Abstract : The kinin system is activated when high-molecular-weight kininogen (HK) is cleaved by plasma kallikrein thus generating bradykinin. Bradykinin is a potent proinflammatory peptide that induces plasma leakage, blood pressure drop, liberation of inflammatory cytokines and pain. READ MORE