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Showing result 1 - 5 of 101 swedish dissertations matching the above criteria.

2. 1. Translational Aspects of Blood-Brain Barrier Transport and Brain Distribution of Drugs in Health and Disease

   Author : Sofia Gustafsson; Margareta Hammarlund-Udenaes; Stina Syvänen; Irena Loryan; Danica Stanimirovic; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Blood-brain barrier; Neurovascular unit; Pharmacokinetics; Neurodegenerative disease; Drug transport; Brain tissue binding; Positron emission tomography; Brain regions; Farmaceutisk vetenskap; Pharmaceutical Science;

   Abstract : A high unmet medical need in the area of CNS diseases coincides with high failure rates in CNS drug development. Efficient treatment of CNS disease is constrained by limited entrance of drugs into the brain owing to the blood-brain barrier (BBB), which separates brain from blood. READ MORE

4. 2. Stereoselective Transport of Drugs Across the Blood-Brain Barrier (BBB) In Vivo and In Vitro : Pharmacokinetic and Pharmacodynamic Studies of the (S)- and (R)-Enantiomers of Different 5-HT1A Receptor Agonists and Antagonists

   Author : Hongmei Yan; Lennart Paalzow; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; pindolol; propranolol; 2- di-n-propylamino tetralin; racemate; enantiomer; drug distribution; brain; rat; blood-brain barrier; Neurovetenskap; Neurology; Neurologi; Psychiatry; psykiatri;

   Abstract : Delivery of drugs to the brain requires passage across the blood-brain barrier (BBB). Both for drugs already on the market and for new drugs under development, it is important to know to what extent a drug enters the CNS. Many drugs used clinically are racemic mixtures, i.e. READ MORE

5. 3. Mammalian brain acetylcholinesterase : a study of its solubilization, purification, molecular state and interactions with cholinergic ligands including an endogenous modulator

   Author : Bertil Niklasson; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Affinity chromatography; caudate nucleus; acetylcholinesterase; tetracaine; décaméthonium; d-tubocurarine; edrophonium; fluoride ion; hysteric properties; endogenous ligands to AChE;

   Abstract : Membrane bound AChE from calf brain caudate nucleus was solubilized by use of ion-free media in presence of 10~ M EDTA and 10“5M tetracaine. The irreversible release of AChE was more effectively inhibited by divalent ions compared to monovalent ions added to the medium. READ MORE

6. 4. Clusterin in brain and cerebrospinal fluidin Alzheimer s disease

   Author : Anna-Maria Nilselid; Göteborgs universitet; []
   Keywords : Alzheimer s disease; clusterin; apolipoprotein J; SP-40; brain tissue; cerebrospinal fluid; glycosylation; biomarker; enzyme-linked immunosorbent assay;

   Abstract : The apolipoprotein clusterin is suggested to be involved in the pathogenesis of Alzheimer¡¦s disease (AD). At the start of these studies, results had indicated that clusterin was elevated in AD brain, compared with controls. READ MORE

7. 5. Molecular Profiling and Imaging of Peptides, Proteins and Drugs in Biological Tissue using Mass Spectrometry

   Author : Anna Nilsson; Per E. Andrén; Garry Corthals; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; peptidomics; mass spectrometry; liquid chromatography; MALDI imaging; neuropeptides; drugs; brain; Pharmacology; Farmakologi;

   Abstract : Biological functions within cells and organisms are mainly carried out by the translational products; proteins and peptides. The analysis and characterization of these biomolecules are of great importance for the progress in disease research and biomarker and drug discovery. READ MORE