Search for dissertations about: "Brain vasculature"

Showing result 1 - 5 of 35 swedish dissertations containing the words Brain vasculature.

  2. 1. The role of PDGF-B in brain blood vessels

    Author : Khayrun Nahar; Christer Betsholtz; Jean-Baptiste Demoulin; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; PFBC; PDGFB; PDGFRB; Brain vasculature; Mural cells;

    Abstract : The development of blood vessels is dependent on several molecular cues to form properly. A functional PDGF-B/PDGFR-b signaling is paramount for the investment of mural cells, that provide with support, to the developing vasculature. READ MORE

  4. 2. Blood Vessels, Biomarkers, and Broken Barriers: lnvestigations of the Brain Vasculature in Models of Neonatal Brain lnjuries

    Author : E. Axel Andersson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neonatal brain injury; hypoxia ischemia; germinal matrix haemorrhage; blood brain barrier; tight‐junctions; blood vessels;

    Abstract : Brain injury during the perinatal period can lead to lifelong impairment in cognitive and motor function, or an early death. Term neonatal encephalopathy and preterm germinal matrix haemorrhage are two conditions that can irreversibly injure the brain, but clinical tools for diagnosing and treating these pathologies are lacking. READ MORE

  5. 3. Molecular Regulation of Vascular Abnormalization and Its Role in Glioma

    Author : Lei Zhang; Anna Dimberg; Rolf Bjerkvig; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glioma; vasculature; pleiotrophin; PTN; CD93; angiogenesis; GL261; RCAS;

    Abstract : Glioblastoma, grade IV glioma, is the one of the deadliest cancers, with a median survival of only 12-15 months despite aggressive treatment including surgery, chemotherapy and radiation. One hallmark of glioblastoma is the morphological and functional abnormalization of tumor blood vessels. READ MORE

  6. 4. PDGFB and P53 in brain tumorigenesis

    Author : Sanna-Maria Hede; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Glioblastoma is the most common, and malignant form of brain tumor. It is characterized by a rapid growth and diffuse spread to surrounding brain tissue. The cell of origin is still not known, but experimental data suggest an origin from a glial precursor or neural stem cell. READ MORE

  7. 5. Prostaglandin E2 in immune-to-brain signaling

    Author : David Engblom; Tamas Bartfai; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Upon immune-challenge, signaling from the immune system to the brain triggers an array of central nervous responses that include fever, anorexia, hyperalgesia and activation of the hypothalamus-pituitary adrenal axis. These symptoms are dependent on cytokines produced at the site of inflammation. READ MORE