Search for dissertations about: "BrdU"

Showing result 6 - 10 of 42 swedish dissertations containing the word BrdU.

  2. 6. Neurogenesis and transplantation in stroke-damaged brain

    Author : Vladimer Darsalia; Lund Neurologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuropsykologi; neuropsychology; neurophysiology; Neurologi; Neurology; Stroke; Transplantation; Stem cells; Aging; Neurogenesis; neurofysiologi;

    Abstract : Stroke in young adult rodents triggers neurogenesis in the damaged striatum and intact hippocampus. as stroke happens frequently in aged individuals it is of great importance to know whether aging affects brain recovery mechanisms. READ MORE

  4. 7. Regulation of Injury Induced Schwann Cell Proliferation Schwann Cell Proliferation

    Author : Åsa Fex Svenningsen; Biologiska institutionen; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; estrogen; signal transduction; insulin like growth-factors; Schwann cell; peripheral; nerve regeneration; Djurfysiologi; Animal physiology; progesterone;

    Abstract : The purpose of this study was to investigate injury induced proliferation of Schwann cells with emphasis of the effects of the insulin-like growth factors (IGF-I and IGF-II) and the sex hormones progesterone and estrogen. Proliferation, measured as [3H] thymidine incorporation, was studied in cultured segments of the rat sciatic nerve or through the use of the thymidine analogue bromo- deoxy-uridine (BrdU) in combination with immunocytochemistry. READ MORE

  5. 8. New neurons and astrocytes in the adult brain. Studies on adult rat neural progenitors in vivo and in vitro with special reference to the effects of IGF-I and CNTF regarding proliferation and lineage determination

    Author : Maria A I Åberg; Göteborgs universitet; []
    Keywords : Brain; hippocampus; rat; neurogenesis; progenitor cell; stem cell; ciliary neurotrophic factor; insulin-like growth factor-I; PI3-K; MAPK.;

    Abstract : The hippocampal dentate gyrus in several species, including man, continues to produce new neurons and glial cells in adulthood. The generation of new neurons and glial cells in the adult hippocampus is under strict regulation. Two major events of significance for cell genesis from progenitor cells are proliferation and lineage determination. READ MORE

  6. 9. Neural stem cells and their contribution to neurogenesis in the adult mammalian brain

    Author : Stefan Momma; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : For a long time it was believed that neurogenesis in the mammalian central nervous system was restricted to the embryonic and early postnatal period. Almost four decades ago Altman and colleagues challenged this notion, but it took more than thirty years before new studies with refined methods convincingly demonstrated neurogenesis in the adult mammalian brain, including the adult monkey and human brain. READ MORE

  7. 10. Neurorestorative strategies involving neurogenesis, neuronal precursors and stem cells in animal models of Parkinson's disease

    Author : Ming Zhao; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Parkinson s disease; substantia nigra pars compacta; adult neurogenesis; stereology; apoptosis; dopamine; tyrosine hydroxylase; nestin; 5-bromodeoxyuridine; [3H]-thymidine; MPTP; 6-OHDA; platelet-derived growth factor-BB;

    Abstract : The general aims of the thesis is to provide evidence for neurogenesis in the adult substantia nigra pars compacta (SNpc), where the dopamine-producing neurons lost in Parkinson's disease (PD) reside; to optimize methods used for detecting newborn nerve cells in adult brain regions with a low rate of neurogenesis; to explore the mechanism of nerve cell death in animal models of parkinsonism and early degenerative and restorative changes in nigral cell populations; and to develop a therapeutic approach that could translate into a future restorative disease-modifying strategy in PD. Paper I. READ MORE