Search for dissertations about: "Breast cancer resistance protein"

Showing result 21 - 25 of 67 swedish dissertations containing the words Breast cancer resistance protein.

  2. 21. PKB/Akt kinase localization and role in stemness maintenance in cancer

    Author : Mayur Vilas Jain; Karin Roberg; Piotr Religa; Mehrdad Rafat; Mahvash Tavassoli; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Cancer incidence rates have increased over the last decade. Currently available therapies are only moderately effective in targeting cancer cells. Established cancer treatment protocols fail to eliminate populations of cancer stem cells (CSCs), which develop resistance against the chemotherapeutic drugs and lead to cancer recurrence. READ MORE

  4. 22. Cell cycle deregulation in breast cancer subgroups and effects on proliferation, migration and tamoxifen resistance

    Author : Sophie Lehn; Malmö Molekylär patologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast cancer; subgroups; proliferation; migration; stem cells; tamoxifen; estrogen receptor;

    Abstract : Breast cancer is a heterogenous disease which can be divided in subgroups of distinct biology with disparate prognosis and response to treatment. The overall aim of this thesis was to delineate subgroup specific behaviour in breast cancer cells with focus on proliferation, migration and stem-like cell activity. READ MORE

  5. 23. Regulation of cellular plasticity and extracellular vesicle secretion in breast cancer

    Author : Chrysoula Tsirigoti; Aristidis Moustakas; Carl-Henrik Heldin; Pierre Savagner; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cellular plasticity; extracellular vesicles; breast cancer; EMT; Molekylär medicin; Molecular Medicine; Molekylär cellbiologi; Molecular Cellbiology;

    Abstract : Epithelial-to-mesenchymal transition (EMT) is a dynamic process controlling the transition of cells between epithelial and mesenchymal states in various physiological or pathological conditions. In cancer, EMT promotes cell dissemination and metastatic colonization, enriches tumors with stem cell populations and confers resistance to anticancer therapy. READ MORE

  6. 24. TGF-β Family Signaling in Tumor Angiogenesis

    Author : Nikolas Eleftheriou; Avdelningen för translationell cancerforskning; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Angiogenesis provides growing tumors a source of nutrients and oxygen, and a route for metastatic dissemination. In recent years anti-angiogenic therapies that primarily target the vascular endothelial growth factor (VEGF) signaling cascade have entered the clinic. READ MORE

  7. 25. A Proteomic Dissection of Breast Cancer - Via Cells and Organelles to Pathways

    Author : Linn Antberg; Institutionen för immunteknologi; []
    Keywords : Proteomics; Mass spectrometry; Breast cancer; DNA repair; Organelle fractionation; Tumour subpopulations;

    Abstract : Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death in females worldwide. Breast tumours are extremely heterogeneous, and each patient’s disease has different causes, prognosis and appropriate treatments associated with it. READ MORE