Search for dissertations about: "Britt-marie Swahn"
Found 1 swedish dissertation containing the words Britt-marie Swahn.
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1. Synthesis and structure activity relationships of competitive NMDA antagonists with analgesic activity
Abstract : The compounds cis-3-(1-oxo-2-phosphonoethyl)-2-piperidinecarboxylic acid 1 and cis-3-(1-hydroxy-2-phosphonoethyl)-2-piperidinecarboxylic acid 2 were synthesized and found to be potent N-methyl-D-aspartate (NMDA) antagonists. NMR analysis showed that 1 prefers a 2eq,3ax chair conformation probably due to a conformer-stabilizing internal hydrogen bond. READ MORE
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