Search for dissertations about: "Bronchoconstriction"

Showing result 16 - 20 of 27 swedish dissertations containing the word Bronchoconstriction.

  2. 16. SAR Studies of Capsazepinod Bronchodilators. The A-ring and the Coupling region

    Author : Maria Dalence; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; COPD; Asthma; Capsazepine; Bronchodilators; Organic chemistry; SAR studies; Organisk kemi;

    Abstract : Bronchoconstriction is a hallmark in respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD). Current therapies use bronchodilating agents in order to control the exacerbations produced by limited airflow and improve the quality of life of patients suffering from these diseases. READ MORE

  4. 17. Quantification of inflammatory mediators to explore molecular mechanisms and sub-phenotypes of asthma

    Author : Johan Kolmert; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : This thesis summarizes a series of studies using liquid chromatography coupled to mass spectrometry methodologies to quantify metabolites of fatty acids (i.e. READ MORE

  5. 18. The role of nitric oxide in porcine models of asthma and acute lung injury

    Author : Roelinde Middelveld; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Nitric oxide (NO) is a modulator of many important physiological processes in the body. It is produced endogenously in several cell types by a family of NO synthases (NOS). READ MORE

  6. 19. Studies on the regulation of leukotriene biosynthesis in antigen presenting cells

    Author : Julia Esser; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Leukotrienes (LTs) are pro-inflammatory lipid mediators with important roles in host de- fense and inflammatory disease. Leukotriene B4 (LTB4) is a potent chemoattractant for neutrophils and contributes to bacterial killing, while the cysteinyl leukotrienes (LTC4, LTD4 and LTE4) elicit increased vascular permeability, bronchoconstriction, eosinophil trafficking and mucus secretion. READ MORE

  7. 20. Airway smooth muscle as a target in asthma : new insights into bronchorelaxation and hyperreactivity

    Author : Martijn Manson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Patients with asthma suffer from reversible airway obstruction accompanied by airway hyperresponsiveness (AHR). Airway smooth muscle (ASM) is central to bronchoconstriction and AHR and is therefore the target of existing and potential new therapies for asthma. READ MORE