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Showing result 1 - 5 of 6 swedish dissertations matching the above criteria.

  2. 1. Gene expression in buccal keratinocytes with emphasis on carbonyl metabolism

    Author : Claudia A Staab; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The inner lining of the cheek, the buccal mucosa, is a target for air-borne, dietary and tobacco usage-derived carcinogens, but also interesting from a drug delivery point of view. Cancer arising in the buccal epithelium, buccal squamous cell carcinoma (BSCC), often diagnosed at a late disease stage, is highly aggressive and recurrent, emphasizing the need for novel approaches in diagnosis and therapy. READ MORE

  4. 2. Recurrent Aphthous Stomatitis - A study, with emphasis on host genetics, oral microbiota composition, and immunoregulatory networks

    Author : Maria Bankvall; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Aphthous stomatitis; Oral mucosa; Oral medicine; Genome-wide association study; Genetic linkage; Association; Genetic polymorphism; Microbiota; Restriction fragment length polymorphism; Antigen-presenting cell; T-lymphocyte; Lymph node; Flow cytometry;

    Abstract : Recurrent aphthous stomatitis (RAS) is one of the most common oral mucosal lesions. The aetiology is unknown and currently there is no consensus regarding suitable treatment regimens. READ MORE

  5. 3. p63 – from expression to function : studies of normal oral mucosa and squamous cell carcinoma of the head and neck

    Author : Niklas Thurfjell; Karin Nylander; Phillip Coates; Göran Roos; Luisa Guerrini; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; p63; SCCHN; p53; BRCA1; Pathology; Patologi;

    Abstract : The human p63 gene discovered in 1997 encodes a series of protein isoforms that differ in their N- and/or C-terminal sequences. These isoforms have widely differing properties in promoting or repressing p53-related functions such as growth arrest and apoptosis. READ MORE

  6. 4. Modeling of multi-step oral carcinogenesis in vitro : assessment of growth, differentiation and apoptosis markers

    Author : Annette Hansson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Organotypic cultures; apoptosis; terminal squamous differentiation; buccal mucosa; cytokeratins; carcinogenesis; p53;

    Abstract : Human oral mucosa, especially the buccal epithelium, is worldwide a common site for cancer. Cancer development frequently results in inactivation of tumor suppressor p53, a central regulator of growth and programmed cell death, and deregulated expression of structural elements like cytokeratins. READ MORE

  7. 5. Effects of 5-fluorouracil on oral barrier functions

    Author : Inger von Bültzingslöwen; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Many anticancer drugs, e.g. 5-fluorouracil (5-FU), may cause oral mucositis and ulcerations. These adverse reactions can be severe and debilitating to the patient, and adjustment of the cancer treatment may be necessary. READ MORE