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Showing result 1 - 5 of 7 swedish dissertations matching the above criteria.

  2. 1. Effects of cytokines on preadipocyte differentiation and Wnt signalling

    Author : Birgit Gustafson; Göteborgs universitet; []
    Keywords : adipocyte differentiation; adiponectin; beta-Catenin; C EBPalpha; IL-6; PPARgamma; TNFalpha; Wnt signalling;

    Abstract : The relationship between amount of adipose tissue, the Metabolic Syndrome and Type 2 diabetes has been recognized for several years. However, the mechanisms for this remain to be clarified. Not all obese individuals develop insulin resistance or Type 2 diabetes and these perturbations are also seen in non-obese individuals. READ MORE

  4. 2. Deciphering the Pathogenesis of Acute Myeloid Leukemia

    Author : Kristian Reckzeh; Avdelningen för molekylärmedicin och genterapi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematopoiesis; Hematopoietic Stem Cell; AML; FLT3; C EBPalpha;

    Abstract : Acute myeloid leukemia (AML) is a malignant disorder of the blood system. Hematopoietic stem cells (HSCs) supply and maintain this system by differentiating via intermediates into lineage-restricted progenitors that strongly proliferate to keep up with the high turn-over of mature blood cells. READ MORE

  5. 3. Studies on function and regulation of the transcription factor C/EBPalpha

    Author : Per Flodby; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The transcription factor C/EBPalpha was originally identified as a protein involved in hepatocyte-specific gene regulation. Later, it has been demonstrated that C/EBPalpha is expressed in several other tissues, mainly in adipose cells, lung, intestine, skin and in myeloid cells. READ MORE

  6. 4. C/EBP transcription factors in lung cellular differentiation and development

    Author : Tove Berg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : C EBP transcription factors; lung; development; differentiation; glucocorticoid regulation;

    Abstract : During embryonic development the lung is lined with a primitive epithelium. As development proceeds, the epithelium matures and differentiates into several cell types that together with cells of mesenchymal origin constitute the adult lung. READ MORE

  7. 5. Transcriptional regulation of differentiation markers in the distal lung epithelium : a role for C/EBP factors

    Author : Tobias Cassel; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Lung; C EBP; Cellular Differentiation; Clara Cell Secretory Protein; Development; Gene Expression; Transcriptional Regulation; CYP21B1; Promoter; Synergism; Nkx2.1;

    Abstract : Late lung development is characterised by extensive cellular differentiation, resulting in a variety of specialised epithelial cell types. Although much is known of the extracellular signalling involved in lung morphogenesis, less is currently known of the intracellular developmental mechanisms that govern cellular differentiation. READ MORE