Search for dissertations about: "C Lagerström"
Showing result 1 - 5 of 11 swedish dissertations containing the words C Lagerström.
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1. Deciphering neural networks in the somatosensory system using single-cell transcriptomics and rabies tracing
Abstract : Itch has evolved to protect us from malicious parasites keen to suck our blood or lay their eggs in our skin. We can detect both the movement of these parasites and the toxins they introduce with specialized neurons called pruriceptors. When we feel an itch, we get a desire to scratch it. READ MORE
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2. Classification, Evolution, Pharmacology and Structure of G protein-coupled Receptors
Abstract : G protein-coupled receptors (GPCR) are integral membrane proteins with seven α-helices that translate a remarkable diversity of signals into cellular responses. The superfamily of GPCRs is among the largest and most diverse protein families in vertebrates. READ MORE
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3. Somatosensory Circuits in the Central Nervous System
Abstract : Spinal glycinergic neurons prevent spontaneous sensations of pain and itch, and development of persistent pain and itch conditions. The glycine receptor alpha 3 subunit (GLRA3) is suggested to be involved in certain inflammatory models, but not in acute nociception. READ MORE
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4. Peripheral Regulation of Pain and Itch
Abstract : Pain and itch are diverse sensory modalities, transmitted by the somatosensory nervous system. Stimuli such as heat, cold, mechanical pain and itch can be transmitted by different neuronal populations, which show considerable overlap with regards to sensory activation. READ MORE
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5. Targeting and driving somatosensory neurons
Abstract : Pain and itch are two distinct sensations, but the fundamental question of how our nervous system distinguishes the processing and encoding of their related information is still far to be clearly delineated. At the spinal cord level, evidences have pointed out specific groups of neurons expressing the gastrin releasing peptide (Grp) and its receptor (Grpr) as responsible for carrying specifically itch-related information. READ MORE