Search for dissertations about: "C-cells"

Showing result 1 - 5 of 10 swedish dissertations containing the word C-cells.

  1. 1. Transcriptional regulation of thyroid development possible interplay of endoderm- and mesoderm-derived morphogenetic signals

    Author : Jessica Westerlund; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : thyroid; congenital hypothyroidism; dysgenesis; Tbx1; Shh; Isl1; Foxa2; C-cells;

    Abstract : Congenital hypothyroidism (CH) affects 1 in 3000 children and is the major cause of treatable mental retardation. Most cases are due to malformations of the gland, collectively named thyroid dysgenesis. The disease results from defective thyroid organogenesis during embryonic life. READ MORE

  2. 2. Influence of Ly49 inhibitory receptors and MHC class I on T cell and NK cell function

    Author : Linda Öberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; NK cell; T cell; Ly49; MHC class I;

    Abstract : Natural Killer cells (NK) can kill virus infected cells and tumor cells but do not harm normal surrounding cells. The function of Ly49 receptors on NK cells is important in maintaining selftolerance since they transmit inhibitory signals when bound to endogenous MHC class I molecules. Their role in T cells is however unclear. READ MORE

  3. 3. Functional role of cerebrospinal fluid contacting cells in the spinal cord and hypothalamus

    Author : Elham Jalalvand; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : Cerebrospinal fluid-contacting (CSF-c) cells are found lining the walls of the central canal and the ventricles throughout the vertebrate phylum, but their function has remained elusive. The aim here was to investigate the physiological role of CSF-c cells in the spinal cord and hypothalamus. READ MORE

  4. 4. Molecular regulation of thyroid development. New mechanisms of normal and defective morphogenesis

    Author : Henrik Fagman; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : thyroid; congenital hypothyroidism; thyroid dysgenesis; cadherins; pharyngeal arch arteries; Shh; Tbx1;

    Abstract : Congenital hypothyroidism (CH) is untreated a major cause of mental retardation. The majority of cases are due to malformations of the gland (dysgenesis). Little is known of molecular mechanisms regulating thyroid morphogenesis. READ MORE

  5. 5. Basic and translational studies of follicular thyroid neoplasia

    Author : Theodoros Foukakis; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Follicular thyroid cancer; follicular thyroid adenoma; PAX8-PPARgamma; PPARgamma; PTEN; RAS; RASSF1A; NORE1A; TERT; quantitative RT-PCR; microarray; cancer biomarker;

    Abstract : Thyroid tumors occur frequently in the general population and although the majority represents benign follicular adenomas (FTA), thyroid cancer constitutes 1% of all malignancies worldwide. Among the differentiated cancers, three main types are recognized, including the papillary and follicular forms (PTC and FTC) that originate from the follicular thyrocytes, and the medullary carcinoma that arises from the C-cells. READ MORE