Search for dissertations about: "C-peptide"
Showing result 1 - 5 of 64 swedish dissertations containing the word C-peptide.
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1. Diabetes mellitus in Adults - Aspects of Incidence, Autoimmunity and C-peptide
University dissertation from Medicine (Lund)Abstract : Popular Abstract in Swedish Diabetes är en livslång kronisk sjukdom som före upptäckten av insulin 1922 ledde till döden inom 0-5 år från debuten vid ungdomsdiabetes, och inom ca 5-20 år vid åldersdiabetes. Användningen av insulin ändrade detta helt. Istället blev långtidskomplikationer ett hot som förkortade och påverkade livet. READ MORE
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2. Molecular aspects of proinsulin C-peptide interactions
University dissertation from Stockholm : Karolinska Institutet, Department of Medical Biochemistry and BiophysicsAbstract : Insulin biosynthesis in the beta-cells of the pancreas begins with the generation of preproinsulin, which is converted to proinsulin. Proinsulin is cleaved into equimolar amounts of insulin and connecting peptide (Cpeptide), which are released into the circulation. READ MORE
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3. Intracellular and peptide interactions of C-peptide
University dissertation from Stockholm : Karolinska Institutet, Dept of Medical Biochemistry and BiophysicsAbstract : Proinsulin C-peptide is depleted together with insulin in type I diabetic patients. The supplement of insulin to these patients is necessary for their survival, but it is also likely that the loss of C-peptide may contribute to both short- and long-term complications. In this thesis, molecular effects of C-peptide have been investigated. READ MORE
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4. Proinsulin C-peptide : Membrane interactions and intracellular signaling
University dissertation from Stockholm : Karolinska Institutet, Department of Surgical ScienceAbstract : In the past decade, new evidence has emerged of a physiological role for C-peptide. C-peptide replacement improves renal and nerve function and augments regional blood flow in type I diabetic patients. READ MORE
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5. C-peptide structural and functional relationships studied by biosensor technology and mass spectrometry
University dissertation from Stockholm : Karolinska Institutet, Department of Medical Biochemistry and BiophysicsAbstract : Proinsulin C-peptide has a number of biological activities and receives interest focusing on the therapeutic potential as a candidate for future co-replacement therapy with insulin in type 1 diabetes. Based on conservation results from comparisons of 22 mammalian proinsulin variants, analogs were constructed for studies of phosphorylation of mitogenactivated protein kinases (MAPKs) in Swiss 3T3 fibroblasts. READ MORE
