Search for dissertations about: "C-terminus"
Showing result 11 - 15 of 125 swedish dissertations containing the word C-terminus.
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11. Amyloid beta aggregation kinetics : The role of intrinsic and extrinsic factors
Abstract : Cerebral senile plaque is one of the main pathologies of Alzheimer's disease (AD). The amyloid cascade hypothesis suggests that the aggregation of amyloid beta (Abeta) peptide is involved in the pathogenesis of AD, which is supported by the fact that Abeta overexpression or production of more aggregation-prone variants lead to early-onset dementia. READ MORE
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12. Structural Studies of Flexible Biomolecules and a DNA-binding Protein
Abstract : The knowledge of the three-dimensional structures of proteins and polypeptides is essential to understand their functions. The work shown in this thesis has two objectives. READ MORE
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13. Viperin, a multifunctional radical SAM enzyme : biogenesis and antiviral mechanisms
Abstract : Viperin (virus-inhibitory protein, endoplasmic reticulum-associated, interferon-inducible) is an interferon-induced antiviral protein. It has three distinct functional domains: the N-terminal domain, the radical SAM (S-adenosylmethionine) domain for binding iron-sulphur cluster, and the C-terminus domain. READ MORE
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14. Creation of new proteins - domain rearrangements and tandem duplications
Abstract : Proteins are modular entities with domains as their building blocks. The domains are recurrent protein fragments with a distinct structure, function and evolutionary history. During evolution, proteins with new functions have been invented through rearrangements as well as differentiation of domains. READ MORE
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15. The Colonization Strategies of Nontypeable Haemophilus influenzae - Bacterial Colonization Factors and Vaccine Development
Abstract : Nontypeable Haemophilus influenzae (NTHi) is a remarkably proficient colonizer of the human respiratory tract. The aim of this thesis has been to characterize currently known, and identify novel, bacterial factors involved in the key processes of colonization and pathogenesis, namely adherence to host tissue and evasion of the host innate immunity. READ MORE