Search for dissertations about: "C1 domain"

Showing result 1 - 5 of 14 swedish dissertations containing the words C1 domain.

  2. 1. The molecular features in PKC epsilon determining its neurite-inducing capacity

    Author : Mia Ling; Institutionen för translationell medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oncology; Cytology; neuroblastoma; neurite outgrowth; C1 domain; cancerology; cancer; onkologi; Cytologi; protein kinase C;

    Abstract : Protein kinase C (PKC) is a family of serine/threonine kinases which are subgrouped into classical (a, bI, bII, g), novel (d, e, h, q) and atypical (z, i/l) isoforms. It has been shown that PKCe induces neurite outgrowth in neuroblastoma cells and the effect is mediated via the regulatory domain. READ MORE

  4. 2. Molecular mechanisms underlying morphological effects of protein kinase C under normal conditions and cellular stress

    Author : Lovisa Sunesson; Institutionen för translationell medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuroblastoma; amytrophic lateral sclerosis; PABPC1; IGF2BP3; G3BP2; peripherin; C1 domain; protein-protein-interactions; Protein kinase C; neurite outgrowth;

    Abstract : The protein kinase C (PKC) family of serine/threonine kinases consists of 10-15 members. The PKC isoforms have central roles in many essential cellular processes, including proliferation, apoptosis, differentiation, cytoskeletal changes, and migration. READ MORE

  5. 3. Localisation of Protein Kinase C in Apoptosis and Neurite Outgrowth

    Author : Anna Schultz; Institutionen för translationell medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; onkologi; cancer; Medicine human and vertebrates ; Medicin människa och djur ; Cytology; oncology; cancerology; Cytologi; Prostate Cancer; Neuroblastoma; Ceramide; Golgi Apparatus; Neurite outgrowth; Apoptosis; Protein Kinase C; C1 domain;

    Abstract : Protein kinase C (PKC) is a family of serine/threonine kinases, which are subgrouped into classical (a, bI, bII, g), novel (d, e, h, q) and atypical (z, i/l) isoforms. One major aim of this thesis work was to investigate if altered levels of PKC isoforms influence the apoptotic responses of malignant cell-lines. READ MORE

  6. 4. Oxygen-dependent regulation of transcription by the hypoxia-inducible factor-1

    Author : Jorge Lira Ruas; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Hypoxia; HIF-1; protein degradation; transcription; coactivators; CBP; subcellular localization; C1-tetrahydrofolate synthase;

    Abstract : Under limited oxygen availability (hypoxia) cells undergo rapid reprogramming in order to survive in the new environment until normoxic conditions are re-established. The observation that hypoxia can induce the expression of genes involved in erythropoiesis, angiogenesis and glucose metabolism among others, led to the identification of the hypoxia-inducible factor-1 (HIF-1) as a master regulator of the hypoxia-response pathway. READ MORE

  7. 5. Chromatin remodeling complexes involved in gene activation by the glucocorticoid receptor

    Author : Annika Wallberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The glucocorticoid receptor (GR) belongs to a large family of ligand-inducible nuclear receptors and consists of a ligand binding domain, a DNA binding domain and transactivation domains. The main transcriptional activation domain, c1, is located in the N-terminus of the receptor. The r1c represents the minimal core activation domain of r1. READ MORE