Search for dissertations about: "C2 receptor"

Showing result 11 - 15 of 17 swedish dissertations containing the words C2 receptor.

  2. 11. Synaptic elimination and the complement system in Alzhaimer's disease

    Author : Jonny Daborg; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Synapse; Alzheimer s disease; Genetics; CSF; Complement; RAGE;

    Abstract : The mechanisms behind Alzheimer’s disease (AD) are largely unknown. The disease is to a large extent hereditary, and the best pathophysiological correlate to the severity of the symptoms is loss of synapses. READ MORE

  4. 12. Biological determinants of HIV infection : studies of viral evolution during disease progression in children and adults

    Author : Åsa Björndal; Karolinska Institutet; Karolinska Institutet; []
    Keywords : HIV-1 HIV-2 biological phenotype genetic subtype chemokine receptors disease progression monocyte-derived macrophages;

    Abstract : Coreceptor usage of primary HIV-1 isolates was analysed in relation to their biological phenotype and the severity of HIV-1 infection in the patient. The indicator cell lines, U87 glioma cells engineered to express CD4 and one of the chemokine receptors CCR1, CCR2b, CCR3, CCR5 or CXCR4, were infected with a panel of well-characterized primary HIV-1 isolates. READ MORE

  5. 13. Immunochemical, biochemical and evolutionary studies on Micrurus nigrocinctus nigrocinctus venom toxins

    Author : Alberto Alape-Girón; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Monoclonal antibody; Phospholipase A2; neurotoxin; myotoxin; protein evolution;

    Abstract : Immunochemical, biochemical and evolutionary studies on Micrurus nigrocinctus nigrocinctus venom toxins Monoclonal antibodies (MAbs) were produced against venom proteins of M. nigrocinctus nigrocinctus, the medically most important elapid of Central America. READ MORE

  6. 14. Development of a protein-free fed-batch process for NS0 cells: studies on regulation of proliferation

    Author : Erika Spens; Lena Häggström; Jean-Louis Goergen; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NS0 myeloma cells; protein-free medium; fed-batch; conditioned medium; autocrine growth factors; abortive proliferation; protease activity; aprotinin; gp130; Bioengineering; Bioteknik;

    Abstract : The overall objective of this study was to investigate how NS0 cell proliferation is regulated in protein-free media. The hypothesis was that during the adaptation to growth factor-free media, animal cell lines start to produce their own autocrine growth factors to support proliferation, and after some time in a culture the effects of these factors are lost which results in cessation of proliferation. READ MORE

  7. 15. The Role of IgM and Complement in Antibody Responses

    Author : Christian Rutemark; Birgitta Heyman; Claus Nielsen; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Complement; antibody response; mutated IgM; natural IgM; complement receptors; SIGN-R1; SAP; CRP; B cells; Medical Science; Medicinsk vetenskap;

    Abstract : An intact complement system including the complement receptors 1 and 2 (CR1/2) is crucial for the generation of a normal antibody response in animals and humans. Moreover, activation of the classical pathway is thought to be important since deficiency in complement components C1q, C2, C4 or C3 lead to impaired antibody responses. READ MORE