Search for dissertations about: "CAR T cells"
Showing result 6 - 10 of 21 swedish dissertations containing the words CAR T cells.
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6. CNS-Targeted Cell Therapy for Multiple Sclerosis
Abstract : Multiple sclerosis (MS) is an autoimmune disorder of the central nervous system (CNS). In the current thesis, we have preformed an immunological investigation of patients with MS and developed an immunosuppressive cell therapy that could be beneficial for these patients. READ MORE
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7. Defining the potential of mesothelin-directed CAR T cells for the treatment of ovarian cancer
Abstract : Chimeric antigen receptor (CAR) T cells have revolutionized the field of immunotherapy, by redirecting T cell specificity and effector functions. Co-stimulation has proven to be crucial for therapeutic effectiveness of CAR T cells and remarkable clinical response rates have been achieved with second generation CD19-directed CAR T cells containing either a CD28 or 4-1BB co-stimulatory domain for the treatment of B cell malignancies. READ MORE
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8. LOAd703 and beyond : Advancing immunostimulatory gene therapy for cancer
Abstract : In the last decade, immunotherapy has come into the limelight of cancer treatments. Immunotherapy aims to stimulate the body’s own immune system to create or reinvigorate anti-tumor immune responses. READ MORE
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9. Allogeneic dendritic cells as adjuvants in cancer immunotherapy
Abstract : In recent years, immunotherapeutic approaches have achieved remarkable successes through checkpoint blockade antibodies, advances in the use of chimeric antigen receptor (CAR) T cells and new insights into the immunosuppressive role of the tumor microenvironment (TME). Through the advances, the role of cancer vaccines based on ex vivo manipulated autologous dendritic cells (DC) has been challenged. READ MORE
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10. Novel immunotherapies for metastatic melanoma - from mouse models towards clinical trials
Abstract : Immunotherapies including checkpoint blockade and adoptive T cell transfer (ACT) show great promise for the treatment of melanoma, with long-term effects in some patients. However, around half of the patients with metastatic malignant melanoma will not be cured with available therapies today, and these patients require other treatment strategies. READ MORE